High-throughput microarray detection of olfactory receptor gene expression in the mouse

Proceedings of the National Academy of Sciences of the United States of America
Xinmin ZhangStuart Firestein

Abstract

The large number of olfactory receptor genes necessitates high throughput methods to analyze their expression patterns. We have therefore designed a high-density oligonucleotide array containing all known mouse olfactory receptor (OR) and V1R vomeronasal receptor genes. This custom array detected a large number of receptor genes, demonstrating specific expression in the olfactory sensory epithelium for approximately 800 OR genes previously designated as ORs based solely on genomic sequences. The array also enabled us to monitor the spatial and temporal distribution of gene expression for the entire OR family. Interestingly, OR genes showing spatially segregated expression patterns were also segregated on the chromosomes. This correlation between genomic location and spatial expression provides unique insights about the regulation of this large family of genes.

References

Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K E RogersF L Margolis
May 21, 1993·Brain Research. Developmental Brain Research·T Margalit, D Lancet
Dec 1, 1995·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·J StrotmannH Breer
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·S L SullivanL B Buck
Dec 1, 1995·Neuron·J FreitagH Breer
May 23, 1998·The Journal of Biological Chemistry·L D WalenskyS H Snyder
Dec 1, 1996·Nature Biotechnology·D J LockhartE L Brown
Sep 10, 1998·Nature Genetics·O ErmolaevaM S Boguski
Jan 23, 1999·Nature Genetics·R J LipshutzD J Lockhart
Apr 15, 1999·Annual Review of Neuroscience·P Mombaerts
May 8, 1999·Gene·J E Tabaska, M Q Zhang
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·E R LimanC Dulac
Jan 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·C Li, W H Wong
May 5, 2001·Genome Research·G GlusmanD Lancet
Sep 15, 2001·Nature·S Firestein
Nov 10, 2001·Annual Review of Genomics and Human Genetics·P Mombaerts
Jan 22, 2002·Nature Neuroscience·Ivan RodriguezPeter Mombaerts
Jan 22, 2002·Nature Neuroscience·Xinmin Zhang, Stuart Firestein
Feb 14, 2002·Journal of Cellular Biochemistry. Supplement·E E SchadtW H Wong
Mar 5, 2002·Human Molecular Genetics·Janet M YoungBarbara J Trask
May 17, 2002·Human Molecular Genetics·Janet M Young, Barbara J Trask
Apr 30, 2003·Neuron·Ian TietjenCatherine Dulac
Jul 3, 2003·Nature Reviews. Neuroscience·Catherine Dulac, A Thomas Torello
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Paul A GodfreyLinda B Buck
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bettina MalnicLinda B Buck
Apr 15, 2004·Genomics·Xinmin ZhangStuart Firestein

❮ Previous
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Citations

Nov 15, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Pascale QuignonFrancis Galibert
Jul 9, 2009·Nature Reviews. Neuroscience·Dong-Jing ZouStuart Firestein
Apr 25, 2009·The Journal of Biological Chemistry·Eva M NeuhausHanns Hatt
Apr 19, 2012·Genome Biology and Evolution·Meng-Shin ShiaoWen-Hsiung Li
Jun 24, 2008·The Journal of Heredity·Silke S SteigerBart Kempenaers
Dec 24, 2008·Molecular Biology and Evolution·Omar De la CruzYoav Gilad
Mar 23, 2013·Nucleic Acids Research·Anne Katrine Alsing, Kim Sneppen
Dec 13, 2006·Cells, Tissues, Organs·A Sbarbati, F Osculati
Jul 3, 2007·BMC Bioinformatics·Nian LiuMinghong Ma
Jul 3, 2010·BMC Genetics·Julie A MennellaDanielle R Reed
Dec 4, 2009·BMC Genomics·Maud RimbaultFrancis Galibert
May 24, 2006·BMC Genomics·Ester FeldmesserDoron Lancet
Apr 10, 2013·BMC Neuroscience·Yuichi FurudonoGraeme Lowe
Oct 18, 2007·BMC Neuroscience·Marijo B Kambere, Robert P Lane
Oct 10, 2009·PLoS Genetics·Shanshan ZhouRobert R H Anholt
Feb 14, 2013·PloS One·Caroline FlegelGünter Gisselmann
Jul 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Diego J Rodriguez-GilCharles A Greer
Dec 24, 2013·Trends in Neurosciences·Arie S MobleyCharles A Greer
Nov 28, 2013·Pharmacology & Therapeutics·Simon R FosterWalter G Thomas
Aug 22, 2013·Molecular and Cellular Neurosciences·Mona KhanPeter Mombaerts
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Luiz Eduardo C Von DanneckerBettina Malnic
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xavier GrosmaitreMinghong Ma
Jun 23, 2011·Annual Review of Neuroscience·Venkatesh N Murthy
Dec 4, 2015·International Journal of Molecular Sciences·Zhenshan WangRunlin Z Ma
Mar 30, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Andrea SbarbatiFrancesco Osculati
Apr 15, 2009·Insect Biochemistry and Molecular Biology·Richard G VogtJoseph C Dickens
Mar 24, 2009·Molecular and Cellular Neurosciences·Stefan H Fuss, Anandasankar Ray
Oct 16, 2007·Current Opinion in Neurobiology·Takeshi Imai, Hitoshi Sakano
Mar 14, 2007·Molecular and Cellular Neurosciences·Junji HirotaPeter Mombaerts
Apr 25, 2015·Nucleic Acids Research·Eleen Y ShumMiles F Wilkinson
Apr 23, 2009·Journal of Neurochemistry·Marc Spehr, Steven D Munger
Aug 27, 2010·Journal of Fish Biology·H HinoH Ueda
Oct 6, 2005·International Journal of Cancer. Journal International Du Cancer·Jinsheng WengMingyao Liu

❮ Previous
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