High-throughput molecular and histopathologic profiling of tumor tissue in a novel transplantable model of murine neuroblastoma: new tools for pediatric drug discovery.

Cancer Investigation
Jimmy K StaufferJon M Wigginton

Abstract

Using two MYCN transgenic mouse strains, we established 10 transplantable neuroblastoma cell lines via serial orthotopic passage in the adrenal gland. Tissue arrays demonstrate that by histochemistry, vascularity, immunohistochemical staining for neuroblastoma markers, catecholamine analysis, and concurrent cDNA microarray analysis, there is a close correspondence between the transplantable lines and the spontaneous tumors. Several genes closely associated with the pathobiology and immune evasion of neuroblastoma, novel targets that warrant evaluation, and decreased expression of tumor suppressor genes are demonstrated. These studies describe a unique and generalizable approach to expand the utility of transgenic models of spontaneous tumor, providing new tools for preclinical investigation.

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Citations

Sep 17, 2013·International Journal of Cancer. Journal International Du Cancer·Michiel KroesenGosse J Adema
Jul 25, 2013·Journal of Cellular Physiology·Maddaly RaviRajesh Bhammar
Apr 9, 2020·Expert Review of Hematology·Manjusha Namuduri, Renier J Brentjens
Feb 3, 2018·International Journal of Oncology·Lindi ChenDeborah A Tweddle

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