High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health Records.

Biological Psychiatry
Thomas H McCoyRoy H Perlis

Abstract

Relying on diagnostic categories of neuropsychiatric illness obscures the complexity of these disorders. Capturing multiple dimensional measures of neuropathology could facilitate the clinical and neurobiological investigation of cognitive and behavioral phenotypes. We developed a natural language processing-based approach to extract five symptom dimensions, based on the National Institute of Mental Health Research Domain Criteria definitions, from narrative clinical notes. Estimates of Research Domain Criteria loading were derived from a cohort of 3619 individuals with 4623 hospital admissions. We applied this tool to a large corpus of psychiatric inpatient admission and discharge notes (2010-2015), and using the same cohort we examined face validity, predictive validity, and convergent validity with gold standard annotations. In mixed-effect models adjusted for sociodemographic and clinical features, greater negative and positive symptom domains were associated with a shorter length of stay (β = -.88, p = .001 and β = -1.22, p < .001, respectively), while greater social and arousal domain scores were associated with a longer length of stay (β = .93, p < .001 and β = .81, p = .007, respectively). In fully adjusted Cox regressi...Continue Reading

Citations

Feb 21, 2019·Psychiatric Services : a Journal of the American Psychiatric Association·Juliet Beni Edgcomb, Bonnie Zima
Dec 21, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Thomas H McCoyRoy H Perlis
Aug 4, 2019·Journal of the American Academy of Child and Adolescent Psychiatry·Mirko UljarevićAntonio Y Hardan
Apr 7, 2021·The American Journal of Psychiatry·Victor M CastroRoy H Perlis
Jun 20, 2021·The Australian and New Zealand Journal of Psychiatry·Mikaela TracyBo Bach
Jul 3, 2021·Journal of the Academy of Consultation-Liaison Psychiatry·Kamber L HartThomas H McCoy
Oct 29, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Mark A Clapp, Thomas H McCoy
Nov 3, 2021·Journal of the American Medical Informatics Association : JAMIA·Ilkin BayramliBen Y Reis

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