High-throughput prediction of tablet weight and trimethoprim content of compound sulfamethoxazole tablets for controlling the uniformity of dosage units by NIR

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Yanhong DongQi Fan

Abstract

This paper establishes a novel method to simultaneously predict the tablet weight (TW) and trimethoprim (TMP) content of compound sulfamethoxazole tablets (SMZCO) by near infrared (NIR) spectroscopy with partial least squares (PLS) regression for controlling the uniformity of dosage units (UODU). The NIR spectra for 257 samples were measured using the optimized parameter values and pretreated using the optimized chemometric techniques. After the outliers were ignored, two PLS models for predicting TW and TMP content were respectively established by using the selected spectral sub-ranges and the reference values. The TW model reaches the correlation coefficient of calibration (R(c)) 0.9543 and the TMP content model has the R(c) 0.9205. The experimental results indicate that this strategy expands the NIR application in controlling UODU, especially in the high-throughput and rapid analysis of TWs and contents of the compound pharmaceutical tablets, and may be an important complement to the common NIR on-line analytical method for pharmaceutical tablets.

References

Apr 22, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael L LandrumMichael A Forgione
Sep 13, 2011·Journal of Pharmaceutical and Biomedical Analysis·Ana Carolina de Oliveira NevesKássio Michell Gomes de Lima
Jan 15, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kristiina JärvinenSven Borchert
Jan 26, 2013·Journal of Pharmaceutical and Biomedical Analysis·Ioan TomutaLuca Liviu Rus
Sep 24, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C-V MöltgenG Reich
Feb 22, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Juan LiRuanqi Wu
Jan 7, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Wei ZhangBing Zhao
Aug 5, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Qian KangQing Wu

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