High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases

World Journal of Gastroenterology : WJG
Mamie GaoDinesh Vyas

Abstract

RNA sequencing is the use of high throughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing can identify differential expression of genes (DEG's), mutated genes, fusion genes, and gene isoforms in disease states. RNA sequencing has been used in the investigation of several colorectal diseases such as colorectal cancer, inflammatory bowel disease (ulcerative colitis and Crohn's disease), and irritable bowel syndrome.

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Citations

Mar 26, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Shuxun WeiWenchao Gao
May 31, 2019·World Journal of Gastroenterology : WJG·Viktor LimanskiyDinesh Vyas
Oct 9, 2020·International Journal of Molecular Sciences·Oana Lelia PopRosita Gabbianelli

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Methods Mentioned

BETA
electrophoresis
PCR
antisense oligonucleotides

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