Abstract
Inhalation injury, which is among the causes of acute lung injury and acute respiratory distress syndrome (ARDS), continues to represent a significant source of mortality in burned patients. Inhalation injury often requires mechanical ventilation, but the ideal tidal volume strategy is not clearly defined in burned pediatric patients. The aim of this study was to determine the effects of low and high tidal volume on the number of ventilator days, ventilation pressures, and incidence of atelectasis, pneumonia, and ARDS in pediatric burned patients with inhalation injury within 1 year post burn injury. From 1986 to 2014, inhalation injury was diagnosed by bronchoscopy in pediatric burned patients (n = 932). Patients were divided into 3 groups: unventilated (n = 241), high tidal volume (HTV, 15 ± 3 mL/kg, n = 190), and low tidal volume (LTV, 9 ± 3 mL/kg, n = 501). High tidal volume was associated with significantly decreased ventilator days (p < 0.005) and maximum positive end expiratory pressure (p < 0.0001) and significantly increased maximum peak inspiratory pressure (p < 0.02) and plateau pressure (p < 0.02) compared with those in patients with LTV. The incidence of atelectasis (p < 0.0001) and ARDS (p < 0.02) was significantl...Continue Reading
References
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·L G McHughL D Hudson
Feb 5, 1998·The New England Journal of Medicine·M B AmatoC R Carvalho
Jul 24, 1998·Burns : Journal of the International Society for Burn Injuries·R MlcakD N Herndon
Aug 17, 2000·The New England Journal of Medicine
Mar 25, 2006·Critical Care Medicine·Jesús VillarArmando Aguirre-Jaime
May 5, 2006·Journal of Intensive Care Medicine·Magda Cepkova, Michael A Matthay
May 23, 2006·The New England Journal of Medicine·UNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials NetworkAndrea L Harabin
Dec 9, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michael D PeckRobert Cartotto
Dec 9, 2008·Journal of Burn Care & Research : Official Publication of the American Burn Association·Tina L PalmieriDavid G Greenhalgh
Oct 13, 2010·Annual Review of Pathology·Michael A Matthay, Rachel L Zemans
Feb 6, 2013·The Journal of Thoracic and Cardiovascular Surgery·Andrew D MaslowThomas Ng
Jul 28, 2013·Respiratory Physiology & Neurobiology·Peter D SlyVincenzo Cannizzaro
Aug 2, 2014·Critical Care Medicine·Pauline de JagerMartin C J Kneyber
Jan 13, 2015·Cancer Informatics·Kellie J ArcherAmanda E Gentry
Citations
Dec 3, 2015·Paediatric Respiratory Reviews·Chong Tien Goh, Stephen Jacobe
Oct 29, 2015·Critical Care : the Official Journal of the Critical Care Forum·Patrick F WalkerKevin K Chung
Jul 6, 2016·Frontiers in Pediatrics·Andreas Schwingshackl, Gianfranco Umberto Meduri
Aug 16, 2016·The New England Journal of Medicine·Robert L Sheridan
Oct 7, 2016·Lancet·Perenlei EnkhbaatarDavid N Herndon
Mar 23, 2017·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kevin N Foster, James H Holmes
Jun 2, 2017·Journal of Burn Care & Research : Official Publication of the American Burn Association·Guillermo FoncerradaOscar E Suman
Jul 3, 2015·Journal of Burn Care & Research : Official Publication of the American Burn Association·Kevin K ChungJames C Jeng
Jul 12, 2017·The Journal of Trauma and Acute Care Surgery·Celeste C FinnertyDavid N Herndon
Oct 11, 2019·BMC Anesthesiology·Peiyi LiJing Lin
Jun 25, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Susanne WiegertVincenzo Cannizzaro
Feb 21, 2018·Annals of Plastic Surgery·Guillermo FoncerradaJong O Lee
Sep 12, 2017·Anaesthesia·A BagchiM Eikermann
Oct 3, 2019·Medicine·Zhi-Guo WangHai-Wang Sha
Apr 24, 2020·Paediatric Anaesthesia·Yi RenJianmin Zhang
Nov 10, 2017·Burns and Trauma·Soman Sen
Nov 20, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Philipp BaumannVincenzo Cannizzaro
Oct 17, 2020·Current Opinion in Anaesthesiology·Rolf Kristian GigengackStephan Alexander Loer
Aug 15, 2020·Anesthesiology Clinics·David Preston, Aditee Ambardekar
Sep 15, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·Travis PerryPriti Parikh