High Times for Painful Blues: The Endocannabinoid System in Pain-Depression Comorbidity

The International Journal of Neuropsychopharmacology
Marie FitzgibbonMichelle Roche

Abstract

Depression and pain are two of the most debilitating disorders worldwide and have an estimated cooccurrence of up to 80%. Comorbidity of these disorders is more difficult to treat, associated with significant disability and impaired health-related quality of life than either condition alone, resulting in enormous social and economic cost. Several neural substrates have been identified as potential mediators in the association between depression and pain, including neuroanatomical reorganization, monoamine and neurotrophin depletion, dysregulation of the hypothalamo-pituitary-adrenal axis, and neuroinflammation. However, the past decade has seen mounting evidence supporting a role for the endogenous cannabinoid (endocannabinoid) system in affective and nociceptive processing, and thus, alterations in this system may play a key role in reciprocal interactions between depression and pain. This review will provide an overview of the preclinical evidence supporting an interaction between depression and pain and the evidence supporting a role for the endocannabinoid system in this interaction.

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M HerkenhamK C Rice
May 1, 1988·Journal of Neurochemistry·K Herrick-Davis, M Titeler
Jan 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·D I Ben-Tovim, M S Schwartz
Oct 4, 1995·Biochemical and Biophysical Research Communications·T SugiuraK Waku
Jul 21, 1994·European Journal of Pharmacology·S N Thorat, H N Bhargava
Jan 1, 1993·Journal of Physiology, Paris·W P Paré, E Redei
Jun 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J D JentschR H Roth
Aug 22, 1997·The Journal of Biological Chemistry·M YuC S Ramesha
Oct 6, 1998·Nature·I D MengH L Fields
Jul 11, 2000·Rheumatology·M Ho, T Pullar
Aug 10, 2000·The Journal of Biological Chemistry·K R KozakL J Marnett
Dec 7, 2000·Chemistry and Physics of Lipids·E V Berdyshev
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·L HanusR Mechoulam
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Amy C PorterChristian C Felder
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Susan M HuangVincenzo Di Marzo
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Diana L Cichewicz, Erin A McCarthy
Sep 6, 2003·Pharmacology, Biochemistry, and Behavior·Reinaldo N TakahashiFabrício L Assini
Jan 7, 2004·British Journal of Pharmacology·James D LeggettD A Kendall
Feb 26, 2004·Current Pain and Headache Reports·Gordon Blackburn-Munro
May 7, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joseph F CheerR Mark Wightman
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Micaela Galante, Marco A Diana
May 26, 2004·PharmacoEconomics·Tore K Kvien
Jun 19, 2004·Stress : the International Journal on the Biology of Stress·Signe F BomholtRuth E Blackburn-Munro
Aug 25, 2004·European Journal of Pain : EJP·Lise GormsenTroels S Jensen

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Citations

Oct 14, 2016·Frontiers in Behavioral Neuroscience·Ning WangFei Luo
Jun 18, 2017·The Journal of Pain : Official Journal of the American Pain Society·Hyochol AhnRoger B Fillingim
Jun 20, 2017·Neuropharmacology·Stephen G WoodhamsVolker Neugebauer
Jul 21, 2017·Journal of Neuroscience Research·Lisa E FlanneryMichelle Roche
Jun 30, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Mohaddeseh Ebrahimi-GhiriMohammad-Reza Zarrindast
Aug 7, 2020·Annals of Neurology·Marina PeballUNKNOWN Collaborators of the Parkinson's Disease Working Group Innsbruck
Nov 9, 2018·Harvard Review of Psychiatry·Waguih William IsHakCharles Louy
Jun 23, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Hung-Yu HuangYi-Wen Lin
Jan 17, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Haley A VecchiarelliMatthew N Hill
May 22, 2020·Neuroscience and Biobehavioral Reviews·Lidia BravoEsther Berrocoso

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