High TNFRSF12A level associated with MMP-9 overexpression is linked to poor prognosis in breast cancer: Gene set enrichment analysis and validation in large-scale cohorts

PloS One
Jungho YangMi Jung Kwon

Abstract

Matrix metalloproteinase-9 (MMP-9) is associated with remodelling of the extracellular matrix and invasion in various cancers. Identifying proteins connected to high MMP-9 expression is important in explaining its mechanisms. Our study aims to shed light on genes associated with high MMP-9 expression and to discuss their clinical impact in breast cancer. We evaluated 173 breast cancer cases from the Kangbuk Samsung Hospital, with 1964 cases from the Molecular Taxonomy of Breast Cancer International Consortium database serving as a validation cohort. We investigated relationships between MMP-9 expression and clinicopathological characteristics. We then used gene set enrichment analyses to detect the association of genes with MMP-9 overexpression, and performed survival analyses to determine the significance of the gene in three independent cohorts. High MMP-9 expression correlated with poor prognosis in univariate and multivariate analyses. Using gene set enrichment analysis, we found that tumour necrosis factor receptor superfamily member 12A (TNFRSF12A) was linked to high MMP-9 expression. In the survival analysis of three published data sets (METABRIC, GSE1456, GSE20685), high TNFRSF12A was relevant to a poor survival rate. H...Continue Reading

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Citations

Oct 28, 2019·Mini Reviews in Medicinal Chemistry·Yutao XieYajun Cao
Apr 4, 2019·BMC Genomics·Alberto Berral-GonzalezGuillermo Ayala
Dec 11, 2019·Molecular Biology Reports·Amani Ahmed AlrehailiTamer Mohamed Abd Elrahman
Dec 18, 2021·Frontiers in Cell and Developmental Biology·ShiJian DingYu-Dong Cai

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Datasets Mentioned

BETA
GSE1456
GSE20685

Methods Mentioned

BETA
dissection
RNA-seq

Software Mentioned

R
GSEA
R package
METABRIC
SPSS

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