High tumor budding stratifies breast cancer with metastatic properties

Breast Cancer Research and Treatment
Bodour SalhiaCoya Tapia

Abstract

Tumor budding refers to single or small cluster of tumor cells detached from the main tumor mass. In colon cancer high tumor budding is associated with positive lymph nodes and worse prognosis. Therefore, we investigated the value of tumor budding as a predictive feature of lymph node status in breast cancer (BC). Whole tissue sections from 148 surgical resection specimens (SRS) and 99 matched preoperative core biopsies (CB) with invasive BC of no special type were analyzed on one slide stained with pan-cytokeratin. In SRS, the total number of intratumoral (ITB) and peripheral tumor buds (PTB) in ten high-power fields (HPF) were counted. A bud was defined as a single tumor cell or a cluster of up to five tumor cells. High tumor budding equated to scores averaging >4 tumor buds across 10HPFs. In CB high tumor budding was defined as ≥10 buds/HPF. The results were correlated with pathological parameters. In SRS high PTB stratified BC with lymph node metastases (p ≤ 0.03) and lymphatic invasion (p ≤ 0.015). In CB high tumor budding was significantly (p = 0.0063) associated with venous invasion. Pathologists are able, based on morphology, to categorize BC into a high and low risk groups based in part on lymph node status. This risk ...Continue Reading

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Citations

Mar 17, 2016·Human Pathology·Svenja ThiesRupert Langer
Oct 20, 2015·Human Pathology·Viktor H KoelzerAlessandro Lugli
May 3, 2016·Journal of Clinical Medicine·Alexandru Dan GrigoreHerbert Levine
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Jul 25, 2019·The American Journal of Surgical Pathology·Mariko TanakaMasashi Fukayama
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Jan 7, 2021·Virchows Archiv : an International Journal of Pathology·Kazuki KawamuraKeiichi Ito
Feb 13, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yaju FengYanrong Liu
Mar 7, 2021·Journal of Clinical Medicine·Paul MozarowskiIoannis A Voutsadakis
May 3, 2021·Journal of Theoretical Biology·D PramanikR Bhat
Jul 22, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Gun Oh ChongJi Young Park
Aug 21, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Parbatraj RegmiFu-Yu Li

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Methods Mentioned

BETA
surgical
biopsies
surgical resection

Software Mentioned

SAS
SPSS

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