High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene

Cancer Cell
Maria I Torres-ArzayusMyles Brown

Abstract

The gene encoding AIB1, an estrogen receptor coactivator, is amplified in a subset of human breast cancers. Here we show that overexpression of AIB1 in transgenic mice (AIB1-tg) leads to mammary hypertrophy, hyperplasia, abnormal postweaning involution, and the development of malignant mammary tumors. Tumors are also increased in other organs, including the pituitary and uterus. AIB1 overexpression increases mammary IGF-I mRNA and serum IGF-I protein levels. In addition, IGF-I receptor and downstream signaling molecules are activated in primary mammary epithelial cells and mammary tumor cells derived from AIB1-tg mice. Knockdown of AIB1 expression in cultured AIB1-tg mammary tumor cells leads to reduced IGF-I mRNA levels and increased apoptosis, suggesting that an autocrine IGF-I loop underlies the mechanism of AIB1-induced oncogenesis.

References

May 1, 1992·The Biochemical Journal·W H Günzburg, B Salmons
Mar 1, 1989·Molecular and Cellular Endocrinology·B Muñoz, F F Bolander
Feb 7, 1981·British Medical Journal·L J KinlenA G Sheil
Feb 15, 1993·Biochemical and Biophysical Research Communications·Y KajimotoT Kamada
Feb 13, 1999·Cell·I Conlon, M Raff
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·N J McKennaB W O'Malley
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jun 22, 2000·International Journal of Cancer. Journal International Du Cancer·C SakakuraH Yamagishi
Jun 24, 2000·Molecular and Cellular Biology·J Font de Mora, M Brown
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z WangM G Rosenfeld
Nov 30, 2000·FEBS Letters·S WerbajhM A Costas
Apr 12, 2001·Genes & Development·A C GingrasN Sonenberg
Jul 19, 2001·The Journal of Biological Chemistry·M G Rosenfeld, C K Glass
Jul 27, 2001·Journal of Mammary Gland Biology and Neoplasia·M P Scheid, J R Woodgett
Oct 27, 2001·Breast Cancer Research and Treatment·H J ListA T Riegel
Jan 5, 2002·Breast Cancer Research and Treatment·D O AzorsaP S Meltzer
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Keiko MiyoshiKhashayarsha Khazaie
Jan 15, 2002·Advances in Experimental Medicine and Biology·D L Hadsell, G Abdel-Fattah
Apr 25, 2002·Molecular and Cellular Biology·Ray-Chang WuBert W O'Malley
May 9, 2002·Molecular and Cellular Biology·Bangyan StilesHong Wu
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Mar 6, 2003·Journal of the National Cancer Institute·C Kent OsborneRachel Schiff
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Lan LiaoJianming Xu
May 28, 2003·Cancer Letters·Derek LeRoith, Charles T Roberts
Jul 5, 2003·Nature Cell Biology·Mauricio J ReginatoJoan S Brugge
Aug 5, 2003·Molecular and Cellular Biology·Raphaëlle Romieu-MourezGail E Sonenshein

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Citations

Feb 10, 2009·International Journal of Colorectal Disease·Petros D GrivasHaralabos Kalofonos
Sep 29, 2011·Human Genetics·Margaret R KaragasKarl T Kelsey
Mar 23, 2007·Breast Cancer Research and Treatment·Michalis V KaramouzisAthanasios G Papavassiliou
May 7, 2009·Breast Cancer Research and Treatment·Tyler LahusenAnna T Riegel
Jun 10, 2009·Breast Cancer Research and Treatment·Marc P J McCaffertyMichael J Kerin
Jul 11, 2006·Clinical & Experimental Metastasis·Rajib Rajhans, Ratna K Vadlamudi
Nov 5, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jun-Min SongBao-Cai Xing
Apr 15, 2009·International Journal of Hematology·Rui LiWen-juan Ke
Apr 2, 2008·Expert Reviews in Molecular Medicine·Sara C Dietz, Jason S Carroll
Jan 1, 2013·Acta Pharmacologica Sinica·Li-jing Yang, Yan Chen
May 3, 2005·Nature Reviews. Cancer·Honami Naora, Denise J Montell
Aug 28, 2007·Nature Reviews. Cancer·Kelly A Green, Jason S Carroll
Aug 25, 2009·Nature Reviews. Cancer·Jianming XuBert W O'Malley
Nov 23, 2013·Nature Reviews. Cancer·David C BerstenMurray L Whitelaw
Dec 23, 2009·Nature Reviews. Clinical Oncology·Ondrej GojisCarlo Palmieri
Apr 10, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·X-G Zhu, S-Y Cheng
Oct 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Agnès CosteJohan Auwerx
Dec 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shu WangJianming Xu
Jul 25, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S AlknerUNKNOWN Swedish and South-East Swedish Breast Cancer Groups
Dec 12, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S AlknerUNKNOWN South Swedish Breast Cancer Group
May 15, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M WeinerO Stål
Jan 7, 2010·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Jun-Hua PengRong-Li Xue
Mar 17, 2006·Acta Pharmacologica Sinica·Jun YanMing-Jer Tsai
Aug 31, 2006·Molecular and Cellular Biology·Anwar HossainGrady F Saunders
Jul 25, 2007·Molecular and Cellular Biology·Larbi AmazitMichael A Mancini
Aug 19, 2005·Molecular and Cellular Biology·Hao YingSheue-Yann Cheng

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