High uptake of antiretroviral therapy among HIV-positive TB patients receiving co-located services in Swaziland

PloS One
Ishani PathmanathanSamson Haumba

Abstract

Swaziland has the highest adult HIV prevalence and second highest rate of TB/HIV coinfection globally. Recently, the Ministry of Health and partners have increased integration and co-location of TB/HIV services, but the timing of antiretroviral therapy (ART) relative to TB treatment-a marker of program quality and predictor of outcomes-is unknown. We conducted a retrospective analysis of programmatic data from 11 purposefully-sampled facilities to evaluate timely ART provision for HIV-positive TB patients enrolled on TB treatment between July-November 2014. Timely ART was defined as within two weeks of TB treatment initiation for patients with CD4<50/μL or missing, and within eight weeks otherwise. Descriptive statistics were estimated and logistic regression used to assess factors independently associated with timely ART. Of 466 HIV-positive TB patients, 51.5% were male, median age was 35 (interquartile range [IQR]: 29-42), and median CD4 was 137/μL (IQR: 58-268). 189 (40.6%) were on ART prior to, and five (1.8%) did not receive ART within six months of TB treatment initiation. Median time to ART after TB treatment initiation was 15 days (IQR: 14-28). Almost 90% started ART within eight weeks, and 45.5% of those with CD4<50/μL...Continue Reading

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Citations

Jan 9, 2020·Journal of the International AIDS Society·Lucia González FernándezSusan Swindells
Jul 10, 2020·PloS One·Prince Justin AnkuAkwasi Kumi-Kyereme
Dec 28, 2018·Tropical Medicine and Infectious Disease·Myo Su KyiVirasakdi Chongsuvivatwong
May 19, 2020·ERJ Open Research·Cristina CalarasuStefan Frent
Jan 15, 2020·Archivos de bronconeumología·Emilio LetangAlberto L García-Basteiro
Jul 3, 2021·International Journal of Environmental Research and Public Health·Mduduzi Colani Shongwe, Song-Lih Huang
Sep 27, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Vannesa Yue May TengCatherine W M Ong
Dec 31, 2021·PloS One·Ncobile Sidzandza Victoria GinaMiriam Mmamphamo Moagi

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