High uptake of L-3-[123I]iodo-alpha-methyl tyrosine in pilocytic astrocytomas

European Journal of Nuclear Medicine
M WeckesserO Schober

Abstract

Despite a favourable prognosis, pilocytic astrocytomas may exhibit signs of malignancy on various neuroimaging modalities. This retrospective analysis was conducted to determine whether scintigraphic features of malignancy are also found on single-photon emission tomography (SPET) using L-3-[123I]iodo-alpha-methyl tyrosine (IMT) as a tracer. Twenty patients with pilocytic astrocytomas were retrospectively selected from a large series of patients referred for the evaluation of primary or recurrent brain tumours. IMT SPET was performed in 16 patients, positron emission tomography (PET) using 2-[18F]fluoro-2-deoxy-D-glucose (FDG) was available in 10 of the patients and SPET using technetium-99m tetrofosmin or thallium-201 had been performed in 11. Image analysis was performed using standard protocols to determine how many patients exceeded the respective thresholds of malignancy. Features of malignancy were found in 7/16 IMT SPET studies, in 7/10 FDG PET studies and in 7/11 of the residual SPET investigations. A significant correlation of tumour size and IMT uptake in primary pilocytic astrocytomas indicated partial volume effects to partly account for the differential uptake behaviour (n = 10, r = 0.87, P < 0.05). Differences in ...Continue Reading

Citations

May 20, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Dirk HellwigSamuel Samnick
Jan 13, 2006·Nuclear Medicine Communications·Frédéric ComteMichel Zanca
Jul 16, 2010·Clinical Nuclear Medicine·Pei-Shan Wu, Wei-Jen Yao
Mar 2, 2012·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Kathy WillowsonClive Baldock
Apr 13, 2002·Neurosurgery·Matthias WeckesserOtmar Schober
Sep 24, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Csaba Juhász, Edit Bosnyák
Dec 20, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Veronika DunklNorbert Galldiks

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