High virus loads in naturally and experimentally SIVagm-infected African green monkeys

Virology
S HolzammerS Norley

Abstract

A quantitative RT-PCR assay was developed for SIVagm and was used to measure the levels of viral RNA in the plasma of experimentally and naturally infected African green monkeys. The number of productively infected PBMCs and the number of cells carrying integrated provirus were also measured. Plasma virus loads in experimentally infected animals peaked at 2 weeks postinfection, ranging from 2.9 x 10(5) to 4.2 x 10(7) RNA copies/ml plasma. Set points of 2.1 x 10(3) to 2.8 x 10(6) RNA copies/ml plasma were maintained for one year. Similarly, the number of cells carrying integrated SIVagm provirus remained relatively stable in individual animals for one year with set points ranging from 73 to 810 proviral copies per 10(6) PBMC. However, the number of productively infected cells fluctuated considerably during this period. Virus loads in the 26 naturally infected AGMs ranged from 8.3 x 10(3) to 1.1 x 10(7) (mean 1.7 x 10(6)) RNA copies/ml plasma. These levels of viremia are similar to those seen in pathogenic systems (HIV-1, SIVmac), indicating that control of SIVagm replication is not the reason for the natural host's resistance to disease progression.

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Citations

Feb 3, 2009·AIDS Research and Human Retroviruses·Isaac SsewanyanaHuyen Cao
Oct 17, 2006·Clinical Microbiology Reviews·Sue VandeWoude, Cristian Apetrei
Jul 29, 2004·Journal of Virology·Binhua LingPreston A Marx
Mar 16, 2006·Journal of Virology·Richard OnangaPierre Roques
Jul 28, 2009·Annual Review of Medicine·Mirko PaiardiniGuido Silvestri
Sep 28, 2006·Blood·Ivona PandreaGuido Silvestri
Mar 29, 2014·Immunogenetics·A AarninkA Blancher
Apr 6, 2004·Journal of Medical Primatology·A GueyeM C Müller-Trutwin
Feb 10, 2009·Journal of Medical Primatology·Guido Silvestri
Dec 17, 2003·Virology·Ivona PandreaCristian Apetrei
Jun 25, 2010·The Journal of General Virology·Gisela García-RamosPhilip H Crowley
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carole ElbimJerome Estaquier

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