High Visceral to Subcutaneous Fat Ratio Is Associated with Increased Postoperative Inflammatory Response after Colorectal Resection in Inflammatory Bowel Disease

Gastroenterology Research and Practice
Yao WeiJieshou Li

Abstract

Excessive postoperative inflammatory response, which is characterized by overproduction of cytokines, often leads to complications after colorectal surgery. However, the impact of body composition on postoperative inflammatory response is largely unknown. The aim of this study is to elucidate whether body fat amount and its distribution affects postoperative inflammation after colorectal surgery in IBD patients. Eighty-six patients undergoing colorectal resection for IBD from June 2014 to Jan 2017 were enrolled. Abdominal CT images within one week prior to surgery were assessed for visceral fat, subcutaneous fat, and muscle mass. Postoperative inflammatory response was evaluated using serum CRP, PCT, and IL-6 levels on postoperative days 1, 3, and 5. Univariate analysis was conducted to identify risk factors for infectious complications. The correlation between body composition and postoperative plasma concentration of inflammatory markers was analyzed using a linear regression model. ROC curve was applied to analyze the effect of different body composition parameters on postoperative infectious complications and to determine the relationship between inflammatory markers and infectious complications. Neither volume of fat or mu...Continue Reading

References

Dec 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Mélanie CôtéJean-Pierre Després
Feb 8, 2011·The Lancet Oncology·Kenneth FearonVickie E Baracos
Oct 14, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Norihiko SugisawaMasanori Terashima
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa MartinVickie E Baracos
Sep 14, 2013·Digestive Diseases·Florian Rieder, Claudio Fiocchi
Oct 14, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Yi LiJieshou Li
Feb 24, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M QuanteS G Tullius
Jul 25, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kostan W ReisingerMartijn Poeze
Sep 24, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Ding ZhaoBo Shen
Oct 8, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·T C HallG Garcea
Oct 17, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Tenghui ZhangJieshou Li
Mar 21, 2016·The British Journal of Surgery·G MalietzisJ T Jenkins
Jun 9, 2016·Annals of Surgery·William AlazawiSatyajit Bhattacharya
Mar 5, 2017·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·W SiekmannA Gupta

❮ Previous
Next ❯

Citations

Jan 2, 2021·World Journal of Gastroenterology : WJG·Giuseppe LosurdoMariabeatrice Principi
Jun 10, 2021·International Journal of Colorectal Disease·Catherine R RowanAoibhlinn O'Toole

❮ Previous
Next ❯

Software Mentioned

Photoshop
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.