High Voltage Dielectrophoretic and Magnetophoretic Hybrid Integrated Circuit / Microfluidic Chip.

Journal of Microelectromechanical Systems : a Joint IEEE and ASME Publication on Microstructures, Microactuators, Microsensors, and Microsystems
David IssadoreR M Westervelt

Abstract

A hybrid integrated circuit (IC) / microfluidic chip is presented that independently and simultaneously traps and moves microscopic objects suspended in fluid using both electric and magnetic fields. This hybrid chip controls the location of dielectric objects, such as living cells and drops of fluid, on a 60 × 61 array of pixels that are 30 × 38 μm(2) in size, each of which can be individually addressed with a 50 V peak-to-peak, DC to 10 MHz radio frequency voltage. These high voltage pixels produce electric fields above the chip's surface with a magnitude , resulting in strong dielectrophoresis (DEP) forces . Underneath the array of DEP pixels there is a magnetic matrix that consists of two perpendicular sets of 60 metal wires running across the chip. Each wire can be sourced with 120 mA to trap and move magnetically susceptible objects using magnetophoresis (MP). The DEP pixel array and magnetic matrix can be used simultaneously to apply forces to microscopic objects, such as living cells or lipid vesicles, that are tagged with magnetic nanoparticles. The capabilities of the hybrid IC / microfluidic chip demonstrated in this paper provide important building blocks for a platform for biological and chemical applications.

References

Jul 12, 2001·Annual Review of Biomedical Engineering·G M WhitesidesD E Ingber
Sep 7, 2001·Biosensors & Bioelectronics·B D DeBusschere, G T Kovacs
Dec 21, 2006·Lab on a Chip·Curtis D ChinSamuel K Sia
Jul 26, 2008·Nature Nanotechnology·Jon Dobson
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiquan CuiChanghuei Yang
Dec 8, 2009·Lab on a Chip·Thomas FrankeAchim Wixforth

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Citations

Jun 2, 2011·Analytical Chemistry·Do Jin ImIn Seok Kang
Nov 1, 2011·Lab on a Chip·Yaochung WengScott R Manalis
Jan 8, 2014·Biomicrofluidics·B ChumoD Issadore
Oct 9, 2013·Advanced Drug Delivery Reviews·Melaku Muluneh, David Issadore
Dec 20, 2016·ACS Applied Materials & Interfaces·Guoyou HuangFeng Xu
Feb 28, 2018·Advanced Materials·Sherjeel M KhanMuhammad M Hussain

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