Higher Adalimumab Drug Levels are Associated with Mucosal Healing in Patients with Crohn's Disease

Journal of Crohn's & Colitis
E ZittanM S Silverberg

Abstract

The current approach to managing the loss of response to anti-tumour necrosis factor (TNF) agents is generally empirical. Prior studies have suggested that adalimumab levels of >4.9 µg/mL are required to achieve clinical remission. Our aim was to identify an optimal adalimumab level to achieve endoscopic healing in Crohn's disease (CD). A cohort of 60 CD patients treated with adalimumab between 2005 and 2013 were reviewed for the study. Demographic and clinical information was obtained from chart review and patient interview. Disease activity was determined using the Harvey-Bradshaw index (HBI), ileocolonoscopy reports and C-reactive protein (CRP) levels. Clinical remission was defined as HBI <5. Endoscopic remission/mucosal healing (MH) was defined as the absence of any ulceration in all ileocolonic segments. Trough adalimumab levels and adalimumab antibody levels were tested using a liquid-phase mobility shift assay. Lower median CRP was significantly associated with MH 1.2mg/dl vs no MH 14.4mg/dl (p = 6.93×10(-6)). Higher adalimumab trough level was significantly associated with MH (median 14.7 µg/mL in those with MH vs 3.4 µg/mL in those without, p = 6.25×10(-5)). Higher adalimumab trough level was also significantly associ...Continue Reading

References

Feb 14, 2003·The New England Journal of Medicine·Filip BaertPaul Rutgeerts
Mar 24, 2011·The American Journal of Gastroenterology·Henit Yanai, Stephen B Hanauer
Aug 24, 2012·Lancet·Ingrid OrdásWilliam J Sandborn
Mar 5, 2013·Journal of Pharmaceutical and Biomedical Analysis·Shui-Long WangSharat Singh
Jul 31, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Xavier RoblinStephane Paul
Jun 11, 2014·The American Journal of Gastroenterology·Xavier RoblinS Paul
Jul 30, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Henit YanaiShomron Ben-Horin
Nov 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bella UngarShomron Ben-Horin

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Citations

Feb 14, 2016·Journal of Crohn's & Colitis·Konstantinos Papamichael, Adam S Cheifetz
Aug 11, 2016·Inflammatory Bowel Diseases·Filipa Silva-FerreiraFernando Magro
Nov 1, 2016·Scandinavian Journal of Gastroenterology·Ashley BondSreedhar Subramanian
Feb 1, 2018·Journal of Crohn's & Colitis·Emily K WrightWilliam R Connell
Jan 3, 2018·Journal of Crohn's & Colitis·Tomer GreenerMark S Silverberg
Oct 21, 2017·Digestive Diseases and Sciences·James P CampbellByron P Vaughn
Jun 1, 2018·Journal of Pediatric Gastroenterology and Nutrition·Dan TurnerRichard K Russell
Aug 24, 2018·Journal of Crohn's & Colitis·Christian MaaserUNKNOWN European Crohn’s and Colitis Organisation [ECCO] and the European Society of Gastrointestinal and Abdominal Radiology [ESGAR
Mar 16, 2019·Expert Review of Clinical Immunology·Jun KatoSakiko Hiraoka
May 3, 2019·Expert Opinion on Biological Therapy·Ciara Egan, Glen A Doherty
Oct 1, 2019·European Journal of Gastroenterology & Hepatology·Nikolas PlevrisCharlie W Lees
Aug 14, 2019·Journal of Crohn's & Colitis·Jean-Frédéric ColombelRemo Panaccione
Apr 12, 2019·Current Opinion in Gastroenterology·Konstantinos Papamichael, Adam S Cheifetz
Jun 28, 2020·International Journal of Colorectal Disease·Mitchell R K L LieC Janneke van der Woude
Nov 15, 2018·Digestive Diseases and Sciences·María ChaparroJavier P Gisbert
Mar 6, 2019·Therapeutic Advances in Gastroenterology·Cátia RochaFernando Magro
Mar 23, 2019·Rheumatology International·José Miguel Senabre GallegoUNKNOWN AIRE-MB Group
Apr 24, 2019·World Journal of Gastroenterology : WJG·Ignacio AlfaroIngrid Ordás
Feb 7, 2017·Alimentary Pharmacology & Therapeutics·S Van SteenbergenM Ferrante
Dec 2, 2017·Expert Opinion on Biological Therapy·Mohammed Razvi, Mark Lazarev
Mar 23, 2017·The American Journal of Gastroenterology·Shail M Govani, Akbar K Waljee
May 16, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Emilio J Laserna-MendietaAlfredo J Lucendo
Mar 28, 2020·United European Gastroenterology Journal·Bella UngarDan Carter
Jul 9, 2020·Biomedicines·Eran ZittanMarc S Berns
Aug 20, 2019·Clinical Pharmacology and Therapeutics·Nathalie Van den BergheDebby Thomas
Jan 27, 2019·Current Treatment Options in Gastroenterology·Christopher MaNiels Vande Casteele
May 31, 2019·Scandinavian Journal of Gastroenterology·Neeraj NarulaJohn K Marshall
Feb 18, 2017·World Journal of Gastroenterology : WJG·Donal Tighe, Deirdre McNamara
Oct 8, 2020·Journal of Crohn's & Colitis·Patrick F van RheenenFrank M Ruemmele

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