Higher adiponectin levels in patients with Berardinelli-Seip congenital lipodystrophy due to seipin as compared with 1-acylglycerol-3-phosphate-o-acyltransferase-2 deficiency

The Journal of Clinical Endocrinology and Metabolism
Barbara Antuna-PuenteJ Magré

Abstract

Human lipodystrophies are characterized by loss of adipose tissue, insulin resistance, and metabolic complications. The mechanisms linking fat loss to severe insulin resistance remain unclear. Adipokines may have important roles as intermediary players in metabolism. We sought to determine the plasma concentrations of leptin and adiponectin in patients with Berardinelli-Seip congenital lipodystrophy (BSCL) harboring mutations in the genes encoding either 1-acylglycerol-3-phosphate-O-acyltransferase-2 (AGPAT2) or BSCL2/seipin, in comparison with patients with other forms of inherited or acquired lipodystrophies or insulin receptor alterations. Leptin and total and high-molecular-weight adiponectin were measured in plasma of 16 BSCL1/AGPAT2 and 19 BSCL2/seipin patients and compared with heterozygous (n = 22) or nonmutated relatives (controls, n = 30); patients with Dunnigan-type partial lipodystrophy due to lamin A/C mutations (n = 23), HIV-related lipodystrophy (n = 124), and insulin receptor dysfunctions caused by mutations or autoantibodies (n = 17). Leptin was dramatically decreased in BSCL patients as compared with other subgroups. Adiponectin was decreased in BSCL as compared with controls and patients with altered insulin ...Continue Reading

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Citations

Sep 13, 2013·Current Diabetes Reports·Camille VatierCorinne Vigouroux
Nov 17, 2010·Nature Reviews. Endocrinology·Christina G FiorenzaChristos S Mantzoros
Feb 25, 2011·The New England Journal of Medicine·Sheetal GandotraCorinne Vigouroux
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Jun 18, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Zefeng ChenZengnan Mo
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Mar 14, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Julliane Tamara Araújo de Melo CamposJosivan Gomes Lima

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