Higher blood hematocrit predicts hyperuricemia: a prospective study of 62,897 person-years of follow-up

Scientific Reports
Chao ZengGuang-Hua Lei

Abstract

This prospective study aimed to investigate the relationship between higher hematocrit (Hct) level and hyperuricemia (HU) incidence. A total of 27,540 subjects were included. Baseline Hct was classified into four categories based on the quartile distribution of the study population. A cox proportional hazards regression was used to evaluate the risk of HU incidence across the Hct quartiles after adjusting a number of potential confounding factors. Out of the 62,897 person-years of follow-up, 2745 new cases of HU were developed. In models adjusted for known risk factors of HU, higher Hct was used to predict HU incidence independently in a graded manner (p = 0.02): compared with subjects in the lowest quartile, subjects in the highest quartile of Hct (hazard ratio = 1.20; 95% confidence interval: 1.03-1.41) were n20% more likely to develop HU. Sensitivity analysis indicated that the hazard ratios increased with the extension of the minimum follow-up interval. When the minimum follow-up interval was restricted to 4 years, subjects in the highest quartile of Hct were 70% more likely to develop HU, compared with the lowest quartile. Higher Hct, a routinely measured inexpensive biomarker was independently associated with the incidenc...Continue Reading

References

Nov 1, 1989·The Journal of Clinical Investigation·Y J YangR N Bergman
Apr 1, 1994·Metabolism: Clinical and Experimental·A MoanS E Kjeldsen
Jan 1, 1994·The Journal of Clinical Endocrinology and Metabolism·H Vuorinen-Markkola, H Yki-Järvinen
Jul 21, 1993·JAMA : the Journal of the American Medical Association·F P CappuccioM Trevisan
May 1, 1996·Diabetes·S G WannametheeA G Shaper
Aug 1, 1996·American Journal of Hypertension·E MuscelliE Ferrannini
Apr 16, 1998·Journal of Hypertension·A HøieggenS E Kjeldsen
Jul 20, 1999·American Journal of Hypertension·Y CinarA B Cinar
May 23, 2001·American Journal of Hypertension·Y CinarK Duman
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Angel ChamorroJohn H Aponte
Jun 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Ashley JeffersonRichard J Johnson
Jun 29, 2002·Journal of the American Academy of Nurse Practitioners·Mary Jo Goolsby
Jan 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michael G ClarkStephen Rattigan
May 17, 2003·Science·Kitt Falk PetersenGerald I Shulman
Nov 25, 2003·American Journal of Epidemiology·Mercedes R CarnethonLloyd E Chambless
Feb 13, 2004·The New England Journal of Medicine·Kitt Falk PetersenGerald I Shulman
May 7, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazufumi NagahamaShuichi Takishita
Jun 4, 2004·The New England Journal of Medicine·Kevin R ShortCraig S Stump
Sep 24, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kunitoshi IsekiShuichi Takishita
Jan 22, 2005·Science·Bradford B Lowell, Gerald I Shulman
Jul 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Tae Woo YooDong Geuk Keum
Sep 19, 2006·Metabolism: Clinical and Experimental·Sofia G TsouliMoses S Elisaf
Mar 14, 2008·Journal of the American Society of Nephrology : JASN·Daniel E WeinerAndrew S Levey
Oct 22, 2008·American Journal of Epidemiology·Leonardo J TamarizFrederick L Brancati
Jun 27, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vasiliki VervitaNeoklis A Georgopoulos
Jul 1, 2009·Arthritis and Rheumatism·Seo Young KimDaniel A Albert
Oct 15, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Maria Léa Corrêa Leite
Oct 17, 2009·Haematologica·Sigrid K BraekkanJohn-Bjarne Hansen
Oct 15, 2010·American Journal of Physiology. Renal Physiology·Toni PetersMichael F Flessner
Jan 6, 2011·Arthritis Research & Therapy·Edward Roddy, Michael Doherty
Feb 9, 2011·Clinical Rheumatology·Somchai UaratanawongR Uaratanawong
Nov 8, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuhei Kawano
Dec 14, 2011·American Journal of Epidemiology·Seungho RyuEliseo Guallar
Jan 21, 2012·Renal Failure·Vassilis FiliopoulosDimosthenis Vlassopoulos

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Citations

Jan 21, 2017·Journal of Clinical Laboratory Analysis·Marzieh EmamianMajid Ghayour-Mobarhan

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