Higher cardiometabolic risk in idiopathic versus autoimmune type 1 diabetes: a retrospective analysis

Diabetology & Metabolic Syndrome
Valentina GuarnottaCarla Giordano

Abstract

Idiopathic type 1 diabetes mellitus (IDM) is characterized by an onset with insulinopenia and ketoacidosis with negative β-cell autoimmunity markers and lack of association with HLA. The aim of the study is to compare the clinical and metabolic parameters, the macro and microvascular complications, the adipose tissue dysfunction and the insulin secretion and sensitivity indexes in patients with IDM and autoimmune type 1 diabetes mellitus (ADM) at clinical onset. Thirty patients with IDM and 30 with ADM, matched for age and gender, were retrospectively analyzed. BMI, waist circumference, lipids, glycemia, HbA1c, insulin requirement, glutamic oxaloacetic and glutamic pyruvic transaminases (GOT and GPT), glucagon stimulated c-peptide (GSC-pep) test levels, M value during hyperinsulinemic euglycemic clamp and Visceral Adiposity Index (VAI) were obtained from our database. Patients with IDM showed a significantly higher BMI (p 0.012), WC (p 0.07), VAI (p 0.004), LDL-cholesterol (p 0.027), GOT (p 0.005), GPT (p 0.001), M value (p 0.006) and GSC-pep peak (p 0.036), with concomitant lower HDL-cholesterol (p < 0.001), than patients with ADM. In addition, patients with IDM showed a more marked familial history for diabetes (p 0.005) and ...Continue Reading

References

Jul 1, 1995·Diabetes·G E UmpierrezL S Phillips
Jun 1, 1996·Diabetes Care·K Yamada, K Nonaka
Mar 3, 1999·Autoimmunity·R Juneja, J P Palmer
Feb 16, 2000·Internal Medicine·S H YanL N Tseng
Feb 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·S I McFarlaneM A Banerji
May 26, 2001·Diabetes Care·A Piñero-PiloñaP Raskin
May 11, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Isabelle Lemieux
Dec 18, 2004·Science·Atsunori FukuharaIichiro Shimomura
May 17, 2011·European Journal of Internal Medicine·Carla GiordanoAldo Galluzzo
Nov 20, 2012·Diabetes·Sanjeet G PatelAshok Balasubramanyam
Jan 3, 2013·European Journal of Clinical Investigation·Nasser M Al-DaghriGeorge P Chrousos
Aug 15, 2015·Journal of Diabetes Research·Matias FabregatAdriana Mimbacas
Sep 23, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·E Lontchi-YimagouE Sobngwi
May 24, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Priyathama Vellanki, Guillermo E Umpierrez

❮ Previous
Next ❯

Citations

Jan 1, 2020·International Journal of Molecular Sciences·Amélie I S Sobczak, Alan J Stewart
May 21, 2019·Clinical Medicine Insights. Endocrinology and Diabetes·Varun PathakReinhold J Medina

❮ Previous
Next ❯

Software Mentioned

SPSS
MedCalc

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.