May 15, 1998

Higher cerebrospinal fluid MHPG in subjects with dementia of the Alzheimer type. Relationship with cognitive dysfunction

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Y I ShelineJ G Csernansky

Abstract

The authors sought to determine the relationships between cerebrospinal fluid (CSF) levels of three neurotransmitter monoamine metabolites and cognitive function. CSF was collected from subjects with dementia of the Alzheimer's type ([DAT] n = 28) and control subjects (n = 10) for determination of CSF 5-hydroxyindole acetic acid (5-HIAA), 3-methoxy-4-hydroxy-phenylglycol (MHPG), and homovanillic acid (HVA) levels. All subjects underwent systematic assessment to determine cognitive function. Subjects with DAT had higher concentrations of CSF MHPG. In the overall sample, cognitive function was inversely correlated with CSF levels of MHPG but not with 5-HIAA or HVA. Within the DAT sample, these correlations did not achieve significance.

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Mentioned in this Paper

Homovanillic Acid
Familial Alzheimer Disease (FAD)
Memory for Designs Test
Severity of Illness Index
Cerebrospinal Fluid
Alzheimer's Disease
Methoxyhydroxyphenylglycol, (-)-Isomer
Neurotransmitters
Cognition Disorders
Homovanillic Acid Measurement

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