Higher circulating levels of IGF-1 are associated with longer leukocyte telomere length in healthy subjects

Mechanisms of Ageing and Development
M BarbieriA Aviv

Abstract

Mutations that inhibit the insulin-like growth factor-1 (IGF-1) extend the lifespan of worms, flies and mice. However, it appears that relatively low circulating levels of IGF-1 in humans are associated with aging-related diseases and diminished longevity. As leukocyte telomere length (LTL) is ostensibly a biomarker of human aging, we examined the relationship between LTL and blood IGF-1 in a healthy cohort. Our sample comprised 476 healthy, unrelated Caucasians (208 men and 268 women), aged 16-104 years, living in the West Coast of Southern Italy. We measured LTL by Southern blots and IGF-1 by enzyme-linked immunoassay. Both IGF-1 and LTL diminished with age (IGF-1, r=-0.601, P<0.001; LTL, r=-0.706, P<0.001). Age-adjusted LTL was positively associated with IGF-1 level throughout the age range of the cohort (r=0.270, P<0.001). IGF-1 accounted for about 10% of the inter-individual variation in LTL over and above the effect of age. Our findings suggest that both circulating IGF-1 and LTL are indices of healthy aging in humans. Further research will be necessary to establish whether LTL will ultimately be used in clinical settings as an index of healthy aging.

References

Dec 2, 1993·Nature·C KenyonR Tabtiang
Nov 7, 1996·Nature·H M Brown-BorgA Bartke
Dec 17, 2002·Nature·Martin HolzenbergerYves Le Bouc
Jan 25, 2003·Experimental Gerontology·Michelangela BarbieriGiuseppe Paolisso
Aug 14, 2003·The Journal of Clinical Endocrinology and Metabolism·Amélie BessonPrimus E Mullis
Jan 25, 2005·Experimental Gerontology·H M Brown-Borg, S G Rakoczy
Aug 27, 2005·Science·Hiroshi KurosuMakoto Kuro-o
Feb 16, 2006·Epidemiology·Claus BischoffKaare Christensen
Aug 17, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Abraham Aviv
Jun 26, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Shawna A CooperJames R Sowers
Jul 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Omer T NjajouWen-Chi Hsueh
Aug 19, 2007·Experimental Gerontology·M BarbieriM Varricchio
Sep 28, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M KimuraA Aviv
Oct 11, 2007·Aging Cell·Stephanie L BakaysaNancy L Pedersen
Mar 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yousin SuhPinchas Cohen
Apr 16, 2008·Heart·Nilesh J Samani, Pim van der Harst
Aug 20, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Darlene E BerrymanJohn J Kopchick
Sep 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bradley J WillcoxJ David Curb
Sep 9, 2008·Endocrinology and Metabolism Clinics of North America·Babak RazaniClay F Semenkovich
Apr 8, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Robert C KaplanAbraham Aviv

❮ Previous
Next ❯

Citations

Feb 12, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·W ChenA Aviv
Nov 15, 2012·Journal of Translational Medicine·Juan E Puche, Inma Castilla-Cortázar
Apr 20, 2014·European Journal of Endocrinology·Anna AulinasSusan M Webb
Mar 16, 2011·Journal of Aging Research·Andrew T Ludlow, Stephen M Roth
Jan 22, 2013·Ageing Research Reviews·Aysel MüezzinlerHermann Brenner
Oct 19, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dana A GleiRosa Ana Risques
Sep 16, 2011·Aging Cell·Athanase BenetosAbraham Aviv
Feb 1, 2013·The British Journal of Dermatology·R NoordamUNKNOWN Leiden Longevity Study group
Mar 29, 2014·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Zbigniew DarzynkiewiczJoseph M Wu
Aug 14, 2013·Clinical Endocrinology·Anna AulinasSusan M Webb
Mar 30, 2016·Diabetologia·Simon VerhulstAthanase Benetos
Apr 17, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alessio SquassinaMaria Del Zompo
Oct 25, 2014·Biodemography and Social Biology·Sarinnapha Vasunilashorn, Alan A Cohen
May 22, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alketa StefaEvangelia Charmandari
Dec 12, 2018·The American Journal of Clinical Nutrition·Marij GielenUNKNOWN TELOMAAS group
Mar 16, 2019·Canadian Journal of Physiology and Pharmacology·Mirna N ChahineAthanase Benetos
Oct 23, 2009·The Journal of Clinical Endocrinology and Metabolism·Sofia Movérare-SkrticClaes Ohlsson
Apr 11, 2017·Aging·Troels SteenstrupAbraham Aviv
Mar 27, 2020·Frontiers in Systems Neuroscience·Robert D Black, Lesco L Rogers
Oct 9, 2012·Cancer Prevention Research·Elissa Epel
Feb 12, 2020·Medical Hypotheses·Oleg A Levada, Alexandra S Troyan
Aug 18, 2020·Molecular and Cellular Endocrinology·Jaanis Lodjak, Simon Verhulst
Aug 14, 2021·Reviews in the Neurosciences·Jessica Daniela SchroderZuleide Maria Ignácio
Apr 8, 2018·Mechanisms of Ageing and Development·Alexander M Vaiserman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

© 2022 Meta ULC. All rights reserved