Higher Education Is Associated with a Lower Risk of Dementia after a Stroke or TIA. The Rotterdam Study

Neuroepidemiology
Saira Saeed MirzaM Arfan Ikram

Abstract

Higher education is associated with a lower risk of dementia, possibly because of a higher tolerance to subclinical neurodegenerative pathology. Whether higher education also protects against dementia after clinical stroke or transient ischemic attack (TIA) remains unknown. Within the population-based Rotterdam Study, 12,561 participants free of stroke, TIA and dementia were followed for occurrence of stroke, TIA and dementia. Across the levels of education, associations of incident stroke or TIA with subsequent development of dementia and differences in cognitive decline following stroke or TIA were investigated. During 124,862 person-years, 1,463 persons suffered a stroke or TIA, 1,158 persons developed dementia, of whom 186 developed dementia after stroke or TIA. Risk of dementia after a stroke or TIA, compared to no stroke or TIA, was highest in the low education category (hazards ratio [HR] 1.46, 95% CI 1.18-1.81) followed by intermediate education category (HR 1.36, 95% CI 1.03-1.81). No significant association was observed in the high education category (HR 0.62, 95% CI 0.25-1.54). In gender stratified analyses, decrease in risk of dementia with increasing education was significant only in men. Higher education is associ...Continue Reading

Citations

Sep 28, 2018·American Journal of Alzheimer's Disease and Other Dementias·Ioannis V ZaganasAlexandros N Vgontzas
Jan 10, 2017·Journal of the International Neuropsychological Society : JINS·Roy P C KesselsFrank-Erik de Leeuw
Jul 4, 2019·Geriatrics & Gerontology International·Chien-Hsun LiYuan-Han Yang
Sep 5, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Elżbieta KuźmaDavid J Llewellyn
Feb 25, 2020·Neurorehabilitation and Neural Repair·Emily RosenichSusan L Hillier
Jun 11, 2020·Journal of Psycholinguistic Research·Aline Minto-GarcíaElsa M Vargas-García
Jul 8, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Alis HeshmatollahM Kamran Ikram

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