Higher frequencies of functional HIV-Envelope specific memory B cells are associated with non-progressive HIV infection in Indian population

AIDS
Jayshree DhandeMadhuri Thakar

Abstract

The HIV-1 specific antibodies are being considered for prevention and therapy in HIV infection. For effective antibody response, presence of functionally competent memory B cells is important; however HIV-infection is known to alter the B cell functionality. Very limited data is available on the HIV-specific memory B cell population in HIV-infected Indian population. In this study, the frequencies of HIV- gp140 specific memory B cells (MEBs) were measured in individuals with non-progressive (LTNPs, N = 20) and progressive (N = 19) HIV infection using multicolor flow cytometry. The activation and functional status of these MEBs were assessed as frequencies and mean fluorescence Intensity (MFI) of the CD38 and CD40 expression respectively. The percentages of gp140+MEBs were higher in LTNPs than seen in progressors (p = 0.0475) and associated with higher CD4 count (p = 0.0312, r = 0.2833). As compared to the progressors, LTNPs also showed higher functional (CD40+) gp140+MEBs (both frequencies (p < 0.0001) and CD40 MFI (p = 0.0222) whereas the frequencies (<0.0001) and the MFI (p = 0.0047) of CD38 expression was significantly lower.. Higher CD4 counts and lower plasma viral load values were associated with higher frequencies of CD4...Continue Reading

References

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