Higher frequency of hepatic steatosis at CT among COVID-19-positive patients.

Abdominal Radiology
Augusto Kreling MedeirosUlysses S Torres

Abstract

Recent studies have demonstrated that obesity is significantly associated with increased disease severity, hospitalizations and mortality in COVID-19, with a potential role in the pathogenesis and prevalence in the new pandemic. The association with hepatic steatosis, however, a condition closely related to obesity within the spectrum of systemic metabolic dysfunctions, remains to be elucidated. We aimed to evaluate the frequency of hepatic steatosis as incidentally detected in chest CT examinations of COVID-19 positive patients in comparison to non-infected controls. A retrospective study was performed with 316 patients (204 RT-PCR positive; 112 RT-PCR negative and chest CT negative). Steatosis was measured with placement of a single ROI in the right lobe of the liver (segments VI-VII) and defined as a liver attenuation value ≤ 40 HU. The frequency of hepatic steatosis was higher in the RT-PCR positive group in comparison to controls (31.9% vs. 7.1%, p < 0.001). Logistic linear regression analysis showed a 4.7 times odds of steatosis in the COVID-19 positive group as compared to controls after adjusting for age and sex (OR 4.698; 95% IC 2.12-10.41, p < 0.001). A significantly higher prevalence of steatosis was found among COVI...Continue Reading

References

Feb 19, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D FestiG Marchesini
Apr 24, 2007·AJR. American Journal of Roentgenology·Yoshihisa KodamaChusilp Charnsangavej
Jun 21, 2008·Journal of Gastroenterology and Hepatology·Elizabeth K SpeliotesCaroline S Fox
Nov 26, 2008·Chronic Respiratory Disease·A T Murugan, G Sharma
Sep 17, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Xiaozhou MaDushyant V Sahani
Feb 23, 2010·AJR. American Journal of Roentgenology·Cody J BoyceJ Louis Hinshaw
Sep 10, 2014·Best Practice & Research. Clinical Gastroenterology·Peter Dietrich, Claus Hellerbrand
Jul 26, 2016·Canadian Journal of Gastroenterology & Hepatology·Malcolm M WellsJeffery Bird
Jun 9, 2017·The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology·Tarek BesheerAbdel Hady El Gilany
Mar 29, 2019·World Journal of Gastroenterology : WJG·Tarek BesheerMahmoud El-Bendary
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Mar 25, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shihua LuoHaibo Xu
Apr 3, 2020·Obesity·Donna H RyanSteven Heymsfield
Apr 10, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer LighterAnna Stachel
Apr 14, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Radwan Kassir
Apr 17, 2020·European Radiology·Wenjing YangMinjie Lu
Apr 22, 2020·Diabetes/metabolism Research and Reviews·Mikiko WatanabeLucio Gnessi
May 8, 2020·Molecular Medicine Reports·Demetrios PetrakisAristidis Tsatsakis
May 12, 2020·Radiology·Rajesh BhayanaAvinash Kambadakone
May 16, 2020·Frontiers in Public Health·Jian-Min JinJin-Kui Yang
May 22, 2020·Journal of Gastroenterology and Hepatology·Feng GaoMing-Hua Zheng
May 23, 2020·Expert Review of Endocrinology & Metabolism·Carl J LavieGiuseppe Lippi
May 24, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Jihye Kim, Jae-Hwan Nam
Jul 6, 2020·Mayo Clinic Proceedings·Fabian Sanchis-GomarGiuseppe Lippi

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Citations

Nov 3, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Margarita V RevzinJohn S Pellerito
Nov 12, 2020·SN Comprehensive Clinical Medicine·Sonali SachdevaHemant Goyal
May 11, 2021·World Journal of Gastroenterology : WJG·Isabela Macedo Lopes Vasques-Monteiro, Vanessa Souza-Mello
May 25, 2021·Archives of Toxicology·Joost BoeckmansTamara Vanhaecke
Jul 3, 2021·Clinical Imaging·Mahmut ÇoraplıHacı Taner Bulut
Jun 26, 2021·World Journal of Gastroenterology : WJG·Anna Di SessaPierluigi Marzuillo
Jul 27, 2021·World Journal of Clinical Cases·Li-Guang Fang, Quan Zhou
Jul 31, 2021·World Journal of Gastroenterology : WJG·Piero BoraschiEmanuele Neri
Jul 15, 2021·The British Journal of Radiology·Lokesh AgarwalKumble Seetharama Madhusudhan
Jul 10, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Maija RadzinaLudmila Viksna
Aug 10, 2021·World Journal of Radiology·Daniel Vasile BalabanMariana Jinga

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS
REDCap

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