Higher HIV RNA Viral Load in Recent Patients with Symptomatic Acute HIV Infection in Lyon University Hospitals

PloS One
Isabelle Girerd-GenessayPhilippe Vanhems

Abstract

Increased human immunodeficiency virus (HIV) virulence at infection has been suggested by a meta-analysis based on viral load and CD4 T lymphocytes (CD4) count during acute infection. This result was obtained after secondary analyses of large databases, facilitating the detection of differences. Similar finding in cohorts of more modest sample size would indicate that the effect could be more substantial. Change from initial CD4 count and HIV viral load after acute HIV infection by calendar year was explored in patients treated at Lyon University hospitals. All patients admitted to our hospitals with acute HIV infection between 1996 and 2013 were included in our study. Initial CD4 count and viral load before the start of anti-retroviral treatment were analyzed. Trends over time were assessed in linear models. Initial CD4 count remained similar over time. However, in 2006-2013, initial viral load rose significantly (+1.12 log10/ml/year, p = 0.01). Our data, obtained from a single hospital cohort, confirmed findings from a large meta-analysis, showed increased initial viremia at acute HIV infection since 2006 and suggesting potentially higher HIV virulence in recent years.

References

Dec 20, 2003·AIDS·Sophie MatheronUNKNOWN French HIV-2 Cohort Study Group
Feb 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cécile GoujardUNKNOWN Agence Nationale de Recherche sur le Sida PRIMO Study Group
May 13, 2006·Epidemiology and Infection·C LewdenUNKNOWN Mortalité 2000 Study Group
Jul 30, 2008·The Journal of Infectious Diseases·T Déirdre HollingsworthChristophe Fraser
Feb 22, 2012·PloS One·Pierre FrangeUNKNOWN French ANRS CO6 PRIMO Cohort Study Group
Oct 2, 2015·The Lancet. HIV·Nikos PantazisUNKNOWN CASCADE Collaboration in EuroCoord

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