Higher human T lymphotropic virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion

The Journal of Infectious Diseases
E L MurphyHTLV Outcomes Study Investigators

Abstract

High human T lymphotropic virus (HTLV)-I provirus load (VL) has been associated with an increased risk of HTLV-associated myelopathy, but little is known about variation in HTLV-I or -II VLs by demographic characteristics and risk behaviors. We measured HTLV-I and HTLV-II VLs in a large cohort of 127 HTLV-I-seropositive and 328 HTLV-II-seropositive former blood donors, by use of real-time polymerase chain reaction using tax primers. Multivariable linear regression was used to control for confounding by relevant covariates. The mean VLs were 3.28 log(10) copies/10(6) peripheral blood mononuclear cells (PBMCs) (range, 0.5-5.3 log(10) copies/10(6) PBMCs) for HTLV-I and 2.60 log(10) copies/10(6) PBMCs (range, 0.05-5.95 log(10) copies/10(6) PBMCs) for HTLV-II (P<.0001). HTLV-II VLs were higher in those subjects with subtype A infection (mean, 2.82 log(10) copies/10(6) PBMCs) than in those with subtype B infection (mean, 2.29 log(10) copies/10(6) PBMCs) (P=.005). Higher HTLV-I VL was associated with previous receipt of a blood transfusion (P=.04), and lower HTLV-II VL was associated with female sex (P=.007). These associations persisted in virus-specific multivariate linear regression models controlling for potential confounding vari...Continue Reading

Citations

Sep 13, 2005·Oncogene·Fernando A ProiettiEdward L Murphy
Apr 5, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark A BeilkePatricia J Kissinger
Aug 3, 2010·AIDS Research and Human Retroviruses·Ana TreviñoUNKNOWN HTLV Spanish Study Group
Mar 24, 2005·Blood·Tamihiro KamataAndrew D Leavitt
May 8, 2010·Blood·Masako IwanagaUNKNOWN Joint Study on Predisposing Factors of ATL Development investigators
May 25, 2005·Retrovirology·Tong-Mao ZhaoThomas J Kindt
Sep 4, 2014·Journal of Neurovirology·Carolina RosadasMarzia Puccioni-Sohler
Jun 28, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Allison WatersWilliam W Hall
Oct 21, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Tzong-Hae LeeEdward L Murphy
Feb 17, 2006·Molecular Aspects of Medicine·F WatzingerT Lion
Feb 5, 2015·Revista Do Instituto De Medicina Tropical De São Paulo·Arthur Paiva, Jorge Casseb
Jul 31, 2014·Revista Da Sociedade Brasileira De Medicina Tropical·Arthur Paiva, Jorge Casseb
Mar 18, 2008·Virus Research·Patrícia MontanheiroJorge Casseb
Nov 27, 2015·Journal of Virology·Maria Fernanda de Castro-AmaranteGenoveffa Franchini
Dec 13, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marco TurciUmberto Bertazzoni
Nov 6, 2015·Journal of Medical Virology·Héctor San MartínEugenio Ramírez
Aug 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·André L A OliveiraWilliam W Hall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Tzong-Hae LeeE L Murphy
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
J E KaplanG B Schreiber
Journal of Virological Methods
Axelle DehéeJean Claude Nicolas
© 2022 Meta ULC. All rights reserved