Higher human T-lymphotropic virus type 1 subtype C proviral loads are associated with bronchiectasis in indigenous australians: results of a case-control study

Open Forum Infectious Diseases
Lloyd EinsiedelAntoine Gessain

Abstract

We previously suggested that infection with the human T-lymphotropic virus type 1 (HTLV-1) subtype C is associated with bronchiectasis among Indigenous Australians. Bronchiectasis might therefore result from an HTLV-1-mediated inflammatory process that is typically associated with a high HTLV-1 proviral load (PVL). Human T-lymphotropic virus type 1 PVL have not been reported for Indigenous Australians. Thirty-six Indigenous adults admitted with bronchiectasis from June 1, 2008, to December 31, 2009 were prospectively recruited and matched by age, sex, and ethno-geographic origin to 36 controls. Case notes and chest high-resolution computed tomographs were reviewed, and pulmonary injury scores were calculated. A PVL assay for the HTLV-1c subtype that infects Indigenous Australians was developed and applied to this study. Clinical, radiological, and virological parameters were compared between groups and according to HTLV-1 serostatus. Human T-lymphotropic virus type 1 infection was the main predictor of bronchiectasis in a multivariable model (adjusted risk ratio [aRR], 1.84; 95% confidence interval [CI], 1.19-2.84; P = .006). Moreover, the median HTLV-1c PVL (interquartile range) for cases was >100-fold that of controls (cases,...Continue Reading

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Citations

Jun 27, 2015·Expert Review of Anti-infective Therapy·David NicolásJosé M Miró
Mar 25, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Lloyd EinsiedelAntoine Gessain
Jul 6, 2015·BMC Infectious Diseases·Shohreh Honarbakhsh, Graham P Taylor
Mar 5, 2018·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sean R BlackallGraeme P Maguire
Nov 3, 2017·PloS One·Luiz Fábio Magno FalcãoJuarez Antônio Simões Quaresma
Nov 1, 2018·Nature Medicine·Amanda B Keener
Dec 14, 2018·Thorax·Adam T HillMichael R Loebinger
Jan 23, 2020·International Journal of STD & AIDS·R J Caswell, K Manavi
Dec 20, 2019·Retrovirology·Sarkis SarkisCynthia A Pise-Masison
Sep 30, 2016·The Medical Journal of Australia·Lloyd J EinsiedelKerry A Taylor
Jul 30, 2017·International Ophthalmology·Rusheng ChewLloyd Einsiedel
Aug 30, 2018·Frontiers in Microbiology·Apio R N DiasJuarez A S Quaresma
Jun 4, 2019·Frontiers in Microbiology·Felicidade Mota PereiraMaria Fernanda Rios Grassi
May 24, 2018·BMC Pulmonary Medicine·Ravishankar ChandrasekaranSanjay H Chotirmall
May 21, 2019·Frontiers in Microbiology·Satoshi Nozuma, Steven Jacobson
Dec 30, 2021·PloS One·Apio Ricardo Nazareth DiasJuarez Antônio Simões Quaresma

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
PCR
bronchoalveolar lavage

Software Mentioned

Picture Archiving and Communication System
Inteleviewer
Stata

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