Higher incidence of chemotherapy induced oral mucositis in females: a supplement of multivariate analysis to a randomized multicentre study

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Samuel VokurkaLubica Misaniová

Abstract

Study on the normal saline vs povidone-iodine mouthwashes for oral mucositis (OM) prophylaxis in patients after high-dose chemotherapy comprising bischloroethyl nitrosourea etoposide ara-C melphalan (BEAM) or high-dose melphalan (HD-L-PAM) followed by autologous peripheral stem cell transplantation indicated that females have higher a incidence of OM compared to men, as reported by [Vokurka et al. 13:554-558, (2005)]. The multivariable analysis of larger cohort of 148 patients compliant with the original study protocol confirmed female gender to be an independent risk factor and predictor for OM. The HD-L-PAM (200 mg/m2) conditioning regimen revealed to be more toxic compared to BEAM as for incidence of OM grades 3-4 World Health Organization score. Body mass index, age, mouthwash solution used, and CD34+ cell number in the autologous graft were verified not to have an impact on OM incidence in this group of patients.

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Citations

Oct 8, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Carlton G BrownKathleen H Mooney
Feb 10, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Mustafa OzturkSelmin Ataergin
Aug 6, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Velia Ramírez-AmadorSergio Ponce-de-León
Feb 19, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Stefan WuketichChristine Marosi
Jan 13, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y-K ChenH-F Tien
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