Higher Levels of a Cytotoxic Protein, Vaginolysin, in Lactobacillus-Deficient Community State Types at the Vaginal Mucosa

Sexually Transmitted Diseases
Rebecca G NowakRebecca M Brotman

Abstract

Vaginolysin (VLY), a cytotoxic protein produced by Gardnerella vaginalis, may contribute to bacterial vaginosis. We observed that women with G. vaginalis, low levels of lactobacilli, history of vaginal douching, higher Nugent scores, and higher vaginal pH had increased VLY. Inflammatory markers were not highly expressed with increasing VLY. Vaginolysin's role in bacterial vaginosis warrants further evaluation.

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Citations

Jul 14, 2020·Frontiers in Cellular and Infection Microbiology·Qian YangWeiguo Lu
Jan 31, 2020·Frontiers in Cellular and Infection Microbiology·Milda Pleckaityte
Nov 9, 2020·Microbial Cell Factories·Wallace Jeng Yang CheeLeslie Thian Lung Than
Jan 28, 2021·Pathogens·Erin M GarciaKimberly K Jefferson

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