Higher levels of circulating CXCL-9 and CXCL-11 in euthyroid women with autoimmune thyroiditis and recurrent spontaneous abortions

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Aynur AktasZiynet Alphan

Abstract

We aimed to measure serum CXCL-9 and CXCL-11 levels in patients with autoimmune thyroiditis (AIT) and recurrent spontaneous abortions (RSA). Forty-one euthyroid, non-pregnant women with AIT and a history of unexplained first trimester RSA, 35 euthyroid women with AIT, and 29 healthy controls matched for age and body mass index were enrolled. Serum CXCL-9 and CXCL-11 were measured. Serum CXCL-9 and -11 levels were significantly higher (p < 0.001 for both) in the antibody-positive women with a history of abortions than in both control groups. Additionally, CXCL-9 levels were higher in patients with AIT without RSA than in healthy controls. No significant differences were found in CXCL-9 and -11 levels in subjects with a history of RSA in relation to the number of previous abortions. In multiple linear regression analyses, abortions were significantly related to CXCL-9 (β-coefficient = 0.174, p < 0.001), CXCL-11 (β-coefficient = 0.490, p < 0.001). Higher circulating levels of CXCL-9 and -11 have been shown in non-pregnant AIT patients with a history of RSA as compared to both control groups, suggesting that this subgroup produce a more dominant Th-1 cytokine profile.

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Citations

Mar 7, 2015·Thyroid : Official Journal of the American Thyroid Association·Xinyi WangWeiping Teng
Dec 22, 2019·The Journal of Clinical Endocrinology and Metabolism·Poupak FallahiAlessandro Antonelli
Sep 26, 2020·Therapeutic Advances in Endocrinology and Metabolism·Liyan LiJunxia Yu
Jun 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaoyun GuoHaixing Jiang

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