Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis

Frontiers in Immunology
Fabián Salas-CuestasConsuelo Romero-Sánchez

Abstract

Both reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activity of patients with SpA remains poorly understood. To evaluate the status of total IgA and SIgA, and the association among the levels of SIgA, IgA, IgA anti-Chlamydia trachomatis, and anti-Shigella spp. with the disease activity measures, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, was compared in a cohort of patients with ReA and uSpA and healthy subjects. This was a cross-sectional study. The serum concentrations of SIgA, IgA anti-C. trachomatis, anti-Shigella spp., and total IgA were measured. Disease activity was measured in each patient by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS). Statistical analysis did include as bivariate evaluation, comparisons by Student's t-test, Kruskal-Wallis test, and U Mann-Whitney test, with a multivariat...Continue Reading

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Citations

Apr 17, 2019·Experimental and Therapeutic Medicine·Daniela CristeaIrina Codita
Jun 13, 2020·Frontiers in Genetics·Weifeng DingXiaodong Zhou
Oct 12, 2018·Nature Reviews. Rheumatology·James T Rosenbaum, Mark Asquith
Jun 12, 2021·Nature Reviews. Rheumatology·Daniele MauroFrancesco Ciccia

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Methods Mentioned

BETA
ESR
ELISA
flow
PCA

Software Mentioned

Stata
FCAP array

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