Higher levels of serum IL-1β and TNF-α are associated with an increased probability of major depressive disorder.

Psychiatry Research
Rajesh DasMd Rabiul Islam

Abstract

Major depressive disorder (MDD) is a debilitating psychiatric disease. The dysregulated cytokines in depression are assumed due to the hyperactivation of the immune system. Here we aimed to evaluate the serum interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in MDD. This study recruited 87 MDD patients and 87 age and sex-matched healthy controls (HCs). The increased levels of serum IL-1β and TNF-α were observed among MDD patients. These higher levels of peripheral markers were positively correlated with the severity of depression. Therefore, the elevated levels of serum IL-1β and TNF-α might be used as risk assessment indicators for depression.

References

Jan 1, 1989·Archives of General Psychiatry·S J SchleiferM Stein
May 1, 1993·Psychological Bulletin·T B Herbert, S Cohen
Jul 9, 2002·Journal of Clinical Pathology·S L JohnstonM M Gompels
Aug 11, 2004·Human Psychopharmacology·Sinead M O'BrienTimothy G Dinan
Dec 27, 2005·Journal of Psychiatric Research·A H Marques-DeakE B A Prado
Aug 25, 2007·Journal of Affective Disorders·M A BremmerW J G Hoogendijk
Aug 5, 2008·Trends in Neurosciences·Carmine M Pariante, Stafford L Lightman
Nov 20, 2008·Frontiers in Neuroendocrinology·Inbal Goshen, Raz Yirmiya
Sep 16, 2010·Psychosomatic Medicine·Winfried RiefJoel E Dimsdale
May 14, 2011·Neuroscience and Biobehavioral Reviews·Simona Cabib, Stefano Puglisi-Allegra
Jun 4, 2011·Archives of Gerontology and Geriatrics·Patrícia E M MarinhoArméle Dornelas de Andrade
Oct 1, 2013·Journal of Psychiatric Research·Rosana MotaManuella P Kaster
Oct 10, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adrian L LoprestiPeter D Drummond
May 20, 2014·Neuroscience Bulletin·Qiu-Qin Han, Jin Yu
Apr 18, 2015·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Scott B PattenJianLi Wang
Apr 19, 2015·Trends in Neurosciences·Scott M ThompsonXiang Cai
May 20, 2015·Journal of Affective Disorders·Hussein Kadhem Al-HakeimArafat Hussein Al-Dujaili
Jun 18, 2016·The Australian and New Zealand Journal of Psychiatry·Paolo CassanoNaomi M Simon
Jan 27, 2017·Biomedical Reports·Rai Khalid FarooqAli Zulqernain
Jun 6, 2017·Human Psychopharmacology·Ni FanHongbo He
Aug 10, 2018·Industrial Psychiatry Journal·Sunil GoyalPookala Shivram Bhat
May 22, 2020·Therapeutic Advances in Psychopharmacology·Sadia AnjumMd Rabiul Islam

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Citations

Apr 21, 2021·The European Journal of Neuroscience·Ellen DoneyCaroline Menard
Aug 11, 2021·Lipids in Health and Disease·Bai RuiyangFu Siqi
Aug 5, 2021·Experimental Physiology·Mohadeseh Gilak-DalasmMohammad Ali Azarbayjani
Oct 13, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiaoyan LiYa Tu

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