Higher optical density of an antigen assay predicts thrombosis in patients with heparin-induced thrombocytopenia

European Journal of Haematology
Fevzi AltuntasRavindra Sarode

Abstract

To correlate optical density and percent inhibition of a two-step heparin-induced thrombocytopenia (HIT) antigen assay with thrombosis; the assay utilizes reaction inhibition characteristics of a high heparin concentration. Patients with more than 50% decrease in platelet count or thrombocytopenia (<150 x 10(9)/L) after exposure to heparin, who had a positive two-step antigen assay [optical density (OD) >0.4 and >50 inhibition with high concentration of heparin] were included in the study. Forty of 94 HIT patients had thrombosis at diagnosis; 54/94 had isolated-HIT without thrombosis. Eight of the isolated-HIT patients developed thrombosis within the next 30 d; thus, a total of 48 patients had thrombosis at day 30. At diagnosis there was no significant difference in OD between HIT patients with thrombosis and those with isolated-HIT. However, OD was significantly higher in all patients with thrombosis (n = 48, 1.34 +/- 0.89), including isolated-HIT patients who later developed thrombosis within 30 d (n = 8, 1.84 +/- 0.64) as compared to isolated-HIT patients who did not develop thrombosis (0.96 +/- 0.75; P = 0.011 and P = 0.008). The Receiver Operative Characteristic Curve showed that OD >1.27 in the isolated-HIT group had a si...Continue Reading

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Citations

Jul 31, 2012·Journal of Thrombosis and Thrombolysis·Connie N HessRenato D Lopes
Nov 7, 2015·International Journal of Laboratory Hematology·N K Sono-KoreeK J Smock
Jun 12, 2009·Journal of Thrombosis and Haemostasis : JTH·S SchneiterL Alberio
Oct 23, 2009·European Journal of Haematology·Kaija JavelaSinikka Koskinen
Jun 4, 2015·Journal of Thrombosis and Thrombolysis·Jacob MarlerCarrie S Oliphant
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Apr 6, 2012·Expert Opinion on Pharmacotherapy·Miriam E Jaax, Andreas Greinacher
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Nov 10, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Sofyan M RadaidehYu-Min Shen
Apr 27, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Jacob L MarlerCarrie S Oliphant
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Sep 20, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Maryam BayatMiguel Salazar

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