Higher platelet P-selectin in male patients with inflammatory bowel disease compared to healthy males

World Journal of Gastroenterology : WJG
J Patrik Fägerstam, Per A Whiss

Abstract

To observe if the total amount of platelet P-selectin (tP-selectin) in patients with inflammatory bowel disease (IBD) was related to disease entity or activity, 5-aminosalicylic acid (5-ASA) medication or gender. tP-selectin was measured by immunoassay in seventeen IBD patients and twelve healthy controls. Compared to controls, there was no difference of tP-selectin in patients related to disease entity or activity and 5-ASA medication. When the groups were split according to gender the male patient group showed higher levels of tP-selectin compared to male controls (153 ng/mL vs 94 ng/mL, P<0.05). Increased tP-selectin levels may alter the inflammatory response and susceptibility to thromboembolic disease. As previously shown with soluble P-selectin, tP-selectin shows gender dependent differences important to consider in future studies.

References

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May 26, 2004·Best Practice & Research. Clinical Gastroenterology·Jacques Cosnes

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Citations

Mar 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·P L BeckR J Xavier
Jan 17, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·O SchreiberL Holm
Aug 17, 2010·Journal of Thrombosis and Thrombolysis·Richard C Becker
Jul 16, 2021·Frontiers in Pharmacology·Ge ZhangRuyi Xue

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