Higher pretreatment lactate dehydrogenase concentration predicts worse overall survival in patients with lung cancer

Medicine
Tai-Bing DengWei-Min Li

Abstract

The aim of this study was to systematically evaluate the prognostic role of pretreatment lactate dehydrogenase (LDH) concentration for survival in patients with lung cancer through performing a meta-analysis. PubMed, EMBASE, Cochrane Library, Web of Science, and China National Knowledge Infrastructure were searched for potentially relevant literature. The study and patients' characteristics were extracted. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were pooled to estimate the prognostic role of LDH in patients with lung cancer. Fourteen studies with 4084 patients were included. Higher pretreatment LDH concentration was significantly associated with an increased risk of overall mortality in patients with lung cancer (HR = 1.49, 95% CI, 1.38-1.59). Subgroup analysis of studies also resulted in a significantly increased risk of mortality in patients with small cell lung cancer (SCLC, HR = 1.54, 95% CI, 1.43-1.67) or nonsmall cell lung cancer (NSCLC, HR = 1.25, 95% CI, 1.06-1.46), with high pretreatment LDH concentration. No significant between-study heterogeneity was observed (I = 12.0%, P = .321). No significant publication bias was found (P = .352) in the meta-analysis. The results suggested that higher pretreat...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Sep 26, 2008·The New England Journal of Medicine·Roy S HerbstScott M Lippman
Feb 10, 2011·CA: a Cancer Journal for Clinicians·Suresh S RamalingamFadlo R Khuri
Jun 3, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael I KoukourakisAdrian L Harris
Oct 4, 2012·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Charlotte E AlmasiIb J Christensen
Feb 21, 2014·Cell Biochemistry and Biophysics·Xinyue WangKai Li
Mar 22, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M FieglW Hilbe
Apr 12, 2014·The Clinical Respiratory Journal·Tuba İnalHüseyin Halilçolar
Nov 3, 2016·The Clinical Respiratory Journal·Umut Sabri KasapogluArmagan Hazar
Aug 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dong Soo LeeYeon Sil Kim
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 21, 2017·Molecular and Clinical Oncology·Suoyuan LiYingqi Hua

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Citations

Aug 25, 2019·Cancers·Yoshitaro ShindoHiroaki Nagano
Apr 8, 2020·Frontiers in Oncology·Fátima BaltazarSara Granja
Dec 29, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Soh Young RyuElani Streja
Mar 30, 2021·Frontiers in Oncology·Jialing WuYimin Liu
May 6, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lauren Averett ByersPeter M Ellis

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