Higher protein intake increases cardiac function parameters in healthy children: metabolic programming by infant nutrition-secondary analysis from a clinical trial

Pediatric Research
Rosa CollellJoaquín Escribano

Abstract

Protein intake may modulate cardiac structure and function in pathological conditions, but there is a lack of knowledge on potential effects in healthy infants. Secondary analysis of an ongoing randomized clinical trial comparing two groups of infants receiving a higher (HP) or lower (LP) protein content formula in the first year of life, and compared with an observational group of breastfed (BF) infants. Growth and dietary intake were assessed periodically from birth to 2 y. Insulin-like growth factor 1 (IGF-1) axis parameters were analyzed at 6 mo in a blood sample. At 2 y, cardiac mass and function were assessed by echocardiography. HP infants (n = 50) showed a higher BMI z-score at 2 y compared with LP (n = 47) or BF (n = 44). Cardiac function parameters were increased in the HP group compared with the LP and were directly related to the protein intake during the first 6 mo of life. Moreover, there was an increase in free IGF-1 in the HP group at 6 mo. A moderate increase in protein supply during the first year of life is associated with higher cardiac function parameters at 2 y. IGF-1 axis modifications may, at least in part, underlie these effects.

References

Apr 1, 1992·International Journal of Cardiology·S S KothariT K Patel
Jul 10, 1991·JAMA : the Journal of the American Medical Association·M S LauerD Levy
Mar 21, 1998·The Journal of Nutrition·A Lucas
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y T ZhouR H Unger
Dec 2, 2000·The American Journal of Clinical Nutrition·N F ButteE O Smith
Feb 5, 2002·Pediatrics·Nicolas StettlerVirginia A Stallings
Jul 28, 2004·The American Journal of Clinical Nutrition·Camilla HoppeKim Fleischer Michaelsen
Nov 13, 2004·Obesity Research·Gianluca IacobellisFrida Leonetti
Aug 20, 2005·Gerontology·Roldano ScognamiglioAngelo Avogaro
Sep 3, 2005·Advances in Experimental Medicine and Biology·Berthold Koletzko
Aug 12, 2006·Nestlé Nutrition Workshop Series. Paediatric Programme·Irene Axelsson
Aug 29, 2006·Nature Reviews. Molecular Cell Biology·Joerg Heineke, Jeffery D Molkentin
Feb 22, 2007·The Journal of Clinical Endocrinology and Metabolism·Patrick MaisonPhilippe Chanson
Mar 27, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Mario PetrettaDomenico Bonaduce
Feb 23, 2008·Clinical and Experimental Pharmacology & Physiology·Julie R McMullen
May 9, 2008·Clinical Endocrinology·Annamaria Colao
Jan 30, 2009·Journal of Anatomy·Simon C Langley-Evans
Mar 27, 2009·The American Journal of Clinical Nutrition·Berthold KoletzkoVeit Grote
Apr 11, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A Seixas Bello MoreiraA Sanchez Moura
Apr 24, 2009·The American Journal of Clinical Nutrition·Berthold KoletzkoUNKNOWN European Childhood Obesity Trial Study Group
Jun 23, 2009·Journal of Pediatric Gastroenterology and Nutrition·Sonia SchiessUNKNOWN European Childhood Obesity Project
Dec 31, 2010·Kidney International·Joaquin EscribanoRicardo Closa-Monasterolo
Jan 15, 2011·Annals of Pediatric Cardiology·Nagla Hassan Abu FaddanHosni Badrawy
Aug 19, 2011·The American Journal of Clinical Nutrition·Piotr SochaUNKNOWN European Childhood Obesity Trial Study Group
Feb 9, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J EscribanoUNKNOWN European Childhood Obesity Trial Study Group
Mar 14, 2014·The American Journal of Clinical Nutrition·Martina WeberUNKNOWN European Childhood Obesity Trial Study Group

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