Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention-A Preview Sub-Study

Nutrients
Grith MøllerAnne Raben

Abstract

Concerns about detrimental renal effects of a high-protein intake have been raised due to an induced glomerular hyperfiltration, since this may accelerate the progression of kidney disease. The aim of this sub-study was to assess the effect of a higher intake of protein on kidney function in pre-diabetic men and women, aged 55 years and older. Analyses were based on baseline and one-year data in a sub-group of 310 participants included in the PREVIEW project (PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World). Protein intake was estimated from four-day dietary records and 24-hour urinary urea excretion. We used linear regression to assess the association between protein intake after one year of intervention and kidney function markers: creatinine clearance, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (ACR), urinary urea/creatinine ratio (UCR), serum creatinine, and serum urea before and after adjustments for potential confounders. A higher protein intake was associated with a significant increase in UCR (p = 0.03) and serum urea (p = 0.05) after one year. There were no associations between increased protein intake and creatinine clearanc...Continue Reading

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Citations

Jul 17, 2020·Journal of the American Society of Nephrology : JASN·Gang-Jee KoShivam Joshi
Oct 3, 2020·Nutrients·Jun Wern YauAmutha Ramadas
Aug 22, 2018·Frontiers in Endocrinology·Mathijs DrummenMargriet Westerterp-Plantenga
Jul 3, 2020·Clinical Interventions in Aging·Wolfgang KemmlerRobert Kob
Sep 4, 2020·Advances in Nutrition·Adela Hruby, Paul F Jacques

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Methods Mentioned

BETA
urine collection

Software Mentioned

eCORE
R Core
PREVIEW
R
ActiSleep
TANITA
iDXA

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