PMID: 11917241Mar 28, 2002Paper

Higher rate of toxicity with no increased efficacy when hydroxyurea is added to a regimen of stavudine plus didanosine and nevirapine in primary HIV infection

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Carlos ZalaPedro Cahn

Abstract

Twenty-four subjects presenting at a single treatment center with primary HIV infection were enrolled in a pilot study aimed to establish the possible role of hydroxyurea in this setting. Study participants were randomly assigned to receive or not to receive hydroxyurea in addition to stavudine (d4T) plus didanosine (ddI) and nevirapine (NVP). Seventy-five percent of patients without hydroxyurea had plasma HIV RNA below 50 copies/mL at 48 weeks by both intention-to-treat (ITT) and on-treatment (OT) analysis in comparison with 50% (ITT) and 67% (OT) of patients with hydroxyurea (p >.1). A median increase of >200 cells/mm3 was observed from baseline to week 48 whether or not hydroxyurea was included in the regimen. Overall, in 12 patients treated with hydroxyurea, 33 adverse events were reported versus 19 reported for 12 patients who did not receive hydroxyurea (p <.05). Our results suggest that that adding hydroxyurea to a regimen of d4T plus ddI and NVP increases toxicity without improving the antiviral effect.

Citations

Oct 3, 2006·Dermatologic Clinics·H Nina Kim, Robert D Harrington
Jan 9, 2004·Infectious Disease Clinics of North America·Sandra L PrestonGeorge L Drusano
Mar 19, 2014·Virology·Caroline P Passaes, Asier Sáez-Cirión
Oct 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Bruno HoenUNKNOWN PRIMSTOP Study Group
Feb 27, 2003·Clinical Pharmacokinetics·Monique M R de MaatJos H Beijnen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.