Higher risk of hyperglycemia in HIV-infected patients treated with didanosine plus tenofovir

AIDS Research and Human Retroviruses
Teresa García-BenayasVincent Soriano

Abstract

The combination of didanosine (ddI) and tenofovir (TDF) has potential advantages, but because of several pitfalls (unexpected decreases in CD4+ T cells, increased risk of pancreatitis) its use has been questioned. Since anecdotal cases of transient insulin-dependent diabetes mellitus were seen in our clinic in patients on ddI + TDF-containing regimens, we explored the rate of this complication in more detail. Retrospective analysis of plasma glucose levels in patients who completed 12 months of treatment with three different triple antiretroviral regimens including ddI + TDF, TDF, or ddI was done. Patients taking antidiabetic drugs and/or those with baseline glucose levels >125 mg/dl were excluded. Weight, age, concomitant antiretrovirals, and ddI dose were assessed. At 12 months without treatment changes, fasting glucose levels were compared to baseline. A multivariate analysis was performed to evaluate which variables were associated with glucose elevations. A total of 177 HIV-infected patients were assessed (78 on ddI + TDF, 42 on TDF, and 57 on ddI). Mean baseline features were well balanced between groups for age (mean, 39 years), gender (78% male), CD4+ count (mean, 507 cells/mm3), weight (mean, 67 kg), and glucose level ...Continue Reading

References

Feb 27, 1993·Lancet·S HigginsS Chandiok
Nov 15, 1993·Annals of Internal Medicine·H AlbrechtK Arastéh
May 12, 2000·The Journal of Biological Chemistry·H MurataM Mueckler
Mar 7, 2003·Lancet·A CarrUNKNOWN HIV Lipodystrophy Case Definition Study Group
Dec 25, 2003·Diabetes Care·UNKNOWN American Diabetes Association
Jan 16, 2004·Lancet·Mary P Martin, Desmond O'Neill
Apr 3, 2004·AIDS·Ana BarriosVincent Soriano
Aug 13, 2004·The New England Journal of Medicine·Andrea De Luca, Simona Di Giambenedetto
Jan 7, 2005·The New England Journal of Medicine·Steven Grinspoon, Andrew Carr
Jan 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Judith C ShlayUNKNOWN Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA)
Jan 27, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Roberto ManfrediFrancesco Chiodo

❮ Previous
Next ❯

Citations

Jun 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bruno LedergerberUNKNOWN Swiss HIV Cohort Study
Apr 23, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carmen de MendozaVincent Soriano
Apr 14, 2010·Expert Opinion on Drug Safety·Sonia Rodriguez-NóvoaVincent Soriano
Oct 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marion G PetersUNKNOWN ACTG Protocol A5127 Team
Feb 6, 2010·HIV Clinical Trials·Carmela PinnettiEnrica Tamburrini
Jan 21, 2016·Journal of Investigative Medicine High Impact Case Reports·Resmi PremjiEric S Nylen
Jan 31, 2019·Journal of the International AIDS Society·Win M HanUNKNOWN IeDEA Asia-Pacific
Jun 23, 2012·European Journal of Epidemiology·Laura GalliAntonella Castagna

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.