Higher sensitivity in the detection of inflammatory brain lesions in patients with clinically isolated syndromes suggestive of multiple sclerosis using high field MRI: an intraindividual comparison of 1.5 T with 3.0 T.

European Radiology
Mike P WattjesHans H Schild

Abstract

The purpose of this study was to determine the sensitivities in the detection of inflammatory lesions in patients with clinically isolated syndromes suggestive of multiple sclerosis at 3.0 T and 1.5 T. MR imaging of 40 patients at both field strengths was performed in separate sessions including contiguous axial slices of T2 turbo spin-echo (T2 TSE), fluid-attenuated-inversion-recovery (FLAIR) and pre- and postcontrast T1 spin-echo (T1 SE). Inflammatory lesions > 3 mm in size were counted and categorized according to their anatomic location. Lesion conspicuity was assessed on a five-point scale. At 3.0 T, 13% more white matter lesions could be identified on the FLAIR sequence and on the T2 TSE sequence. Compared to 1.5 T 7.5% more contrast-enhancing lesions were detected at 3.0 T. The higher detection rate at 3.0 T was significant for the infratentorial (p = 0.02) and juxtacortical (p < 0.01) region on the FLAIR as well as for the infratentorial (p = 0.03), juxtacortical (p = 0.02) and periventricular (p = 0.03) region on the T2 TSE sequence. The lesion conspicuity was significantly better at 3.0 T for FLAIR and T2 TSE sequences (p<0.01; p=0.01). In conclusion, high-field MRI at 3.0 T provides a significantly higher detection r...Continue Reading

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Citations

Mar 12, 2009·Neuroradiology·Mike P Wattjes, Frederik Barkhof
Dec 25, 2010·European Radiology·Frederik BarkhofMike P Wattjes
May 1, 2008·Journal of Neurology·Mike P WattjesFrederik Barkhof
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Mohit NeemaRohit Bakshi
Oct 3, 2008·International Journal of Technology Assessment in Health Care·Mohammad PaleshMax Petzold
Jul 24, 2008·Investigative Radiology·Jacobus F A JansenWalter H Backes
May 6, 2014·Clinical Neurology and Neurosurgery·Hiroshi KataokaSatoshi Ueno
Jun 3, 2014·Journal of the Neurological Sciences·Georgina Arrambide, Jaume Sastre-Garriga
Jun 12, 2012·European Radiology·Joanna M WardlawUNKNOWN SINAPSE Collaborative Group
May 30, 2008·European Radiology·Bastiaan MoraalFrederik Barkhof
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May 28, 2010·The British Journal of Radiology·R J MillsE T Smith
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Jun 30, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Renxin ChuRohit Bakshi
May 3, 2012·Neuroimaging Clinics of North America·Iris D KilsdonkMike P Wattjes
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Jul 23, 2015·Clinical Neuroradiology·M P WattjesM Stangel
May 9, 2015·Radiologic Clinics of North America·Lubna BhattiMustafa R Bashir
Jun 12, 2008·Arquivos de neuro-psiquiatria·Pedro BelezaJosé Figueiredo
Dec 29, 2007·European Journal of Radiology·Winfried A Willinek, Hans H Schild
Jan 24, 2018·Cold Spring Harbor Perspectives in Medicine·Christopher C Hemond, Rohit Bakshi

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