Higher serum cholesterol and decreased Parkinson's disease risk: A statin-free cohort study

Movement Disorders : Official Journal of the Movement Disorder Society
Violetta RozaniChava Peretz

Abstract

Higher levels of serum cholesterol are well-established risk factors for coronary artery disease and stroke. The role of serum cholesterol in neurodegeneration is not clear. We evaluated the association between serum cholesterol levels over time and the risk of Parkinson's disease (PD) among statin-free individuals. A population-based cohort study of 261,638 statin-free individuals (aged 40-79 years at their first serum cholesterol test, 42.7% men), with repeated measures of total, low, and high-density lipoprotein cholesterol was performed from 1999 to 2012. Individuals were followed from their first cholesterol test until PD incidence, death, or end of study. The PD incidence was assessed using a validated antiparkinsonian-drug tracing approach. Cox models stratified by sex and age with time-dependent cholesterol variables were applied to estimate PD hazard ratios. A total of 764 (3.3% patients aged 65 + years) incident PD cases were detected during a mean follow-up of 7.9 (±3.6) years. Among men, the middle and upper tertiles of total and low-density lipoprotein cholesterol compared to the lowest were significantly associated with a lower PD risk. Age-pooled hazard ratios (95% confidence interval) for middle and upper tertil...Continue Reading

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Jan 10, 2019·Cells·Helena XicoyGerard J M Martens
Apr 3, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Su-Min JeongDong Wook Shin
Jan 18, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Connie Marras, Jose A Obeso
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Dec 15, 2021·The European Journal of Neuroscience·Wenjing ShenYingzhu Chen

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