Higher serum creatinine concentrations in black patients with chronic kidney disease: beyond nutritional status and body composition.

Clinical Journal of the American Society of Nephrology : CJASN
Joy HsuGlenn M Chertow

Abstract

Serum creatinine concentrations tend to be higher in black than white individuals and people of other races or ethnicities. These differences have been assumed to be largely related to race-related differences in body composition, especially muscle mass. In a diverse population of hemodialysis patients, we compared mean serum creatinine concentrations in black versus nonblack patients, adjusting for case mix (age, gender, diabetes, and dialysis vintage), body size (height, weight), laboratory parameters of nutritional status (albumin, predialysis blood urea nitrogen, transferrin, phosphorus, glucose), dialysis dosage (urea reduction ratio), and parameters of bioelectrical impedance (resistance and reactance), proxies for body composition. Adjusted mean serum creatinine concentrations were significantly higher in black versus nonblack patients (11.7 versus 10.0 mg/dl; P < 0.0001). Black patients were roughly four-fold more likely to have a serum creatinine concentration >10 mg/dl and six-fold more likely to have a serum creatinine concentration >15 mg/dl. Higher serum creatinine concentrations were associated with a lower relative risk for death (0.93; 95% confidence interval 0.88 to 0.98 per mg/dl); the association was slightly...Continue Reading

References

Aug 1, 1979·The American Journal of Clinical Nutrition·J H HimesR M Siervogel
Jan 1, 1991·Nephron·S Giovannetti, G Barsotti
Nov 1, 1985·Kidney International·O ShemeshB D Myers
Jul 1, 1989·Journal of the American Geriatrics Society·D H SullivanD A Lipschitz
Apr 1, 1987·The American Journal of Clinical Nutrition·R J KuczmarskiG G Koch
Apr 1, 1986·Journal of Applied Physiology·H C LukaskiW A Siders
Apr 1, 1985·The American Journal of Clinical Nutrition·H C LukaskiG I Lykken
Apr 1, 1980·Clinical Science·W E MitchM Walser
Jul 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A J BleyerJ M Burkart
Sep 1, 1996·The American Journal of Clinical Nutrition·R Roubenoff
Jul 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P GoldwasserM Maru
Jan 4, 1998·Kidney International·G M ChertowE G Lowrie
Jul 21, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J CoreshF Van Lente
Jul 21, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J E LeggatF K Port
Dec 8, 1998·JAMA : the Journal of the American Medical Association·W F OwenE G Lowrie
Dec 18, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C A JonesL Y Agodoa
Apr 9, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·O IfuduE A Friedman
Apr 14, 1999·Kidney International·E FleischmannA K Salahudeen
Oct 12, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D L FrankenfieldW F Owen
Jan 29, 2000·Kidney International·C O Stehman-BreenM Caps
Nov 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M M TannaS M Korbet
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Paul MuntnerPaul K Whelton
Jul 26, 2002·Journal of the American Society of Nephrology : JASN·Donal ReddanUNKNOWN National ESRD CPM Work Group
Sep 18, 2002·Kidney International·Ronald M A HenryCoen D A Stehouwer
Oct 10, 2002·Kidney International·Srinivasan BeddhuJeffrey L Anderson
Feb 7, 2003·Journal of the American College of Cardiology·Guruprasad ManjunathMark J Sarnak
Feb 25, 2003·JAMA : the Journal of the American Medical Association·Ashwini R Sehgal
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Harini A ChakkeraGlenn M Chertow
Jun 1, 2005·The American Journal of Medicine·Donald MorrisSrinivasan Beddhu

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Citations

Dec 17, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carlo BasileBiagio Di Iorio
Sep 5, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Ariana Aguiar SoaresSandra Pinho Silveiro
Apr 26, 2014·The American Journal of the Medical Sciences·Nancy G KutnerJanice Lea
Apr 18, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Natália Maria da Silva FernandesJosé Carolino Divino-Filho
Jun 18, 2010·Kidney International·Sushrut S WaikarJoseph V Bonventre
Jan 12, 2010·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Antonio Alberto LopesFriedrich K Port
Dec 18, 2009·Clinical Transplantation·A Reeves-DanielK R Daniel
Jun 13, 2014·Pediatric Transplantation·Joshua D SparksCharles E Canter
Jul 7, 2009·International Journal of Nursing Studies·Jing ZhengCui-Qiu Zhai
Sep 22, 2009·Clinics in Geriatric Medicine·Sarbjit Vanita Jassal
May 2, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Stephan ThijssenNathan W Levin
Jun 7, 2019·JAMA : the Journal of the American Medical Association·Nwamaka Denise EneanyaPeter Philip Reese
Aug 28, 2020·The New England Journal of Medicine·Darshali A VyasDavid S Jones
Mar 8, 2017·International Urology and Nephrology·Cristina GaragarzaAna Paula Silva
Jan 1, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lara C Pullen
Apr 3, 2021·Urology·Fernandino L VilsonJohn T Leppert
Apr 11, 2021·Journal of the American Society of Nephrology : JASN·Cynthia DelgadoNeil R Powe
Apr 13, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cynthia DelgadoNeil R Powe
Aug 31, 2021·Current Opinion in Nephrology and Hypertension·Pierre DelanayeHans Pottel

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