Higher serum levels of uric acid are associated with a reduced insulin clearance in non-diabetic individuals

Acta Diabetologica
Teresa Vanessa FiorentinoGiorgio Sesti

Abstract

Decreased insulin clearance has been reported to be associated with insulin resistance-related disorders and incident type 2 diabetes. The aim of this study was to evaluate whether higher levels of uric acid (UA), a known risk factor of type 2 diabetes, are associated with a reduced insulin clearance. 440 non-diabetic individuals were stratified in tertiles according to serum UA levels. Insulin clearance and skeletal muscle insulin sensitivity were assessed by euglycemic hyperinsulinemic clamp. Hepatic insulin resistance was estimated by the liver IR index. Subjects with higher levels of UA displayed an unfavorable metabolic phenotype with a worse lipid profile, increased levels of 2-h post-load glucose levels, fasting, and 2-h post-load insulin levels, hsCRP, liver IR index, and lower levels of eGFR and skeletal muscle insulin sensitivity, in comparison to individuals with lower UA levels. Moreover, subjects with higher UA concentrations exhibited decreased levels of insulin clearance even after adjustment for age, gender, BMI, eGFR, and skeletal muscle insulin sensitivity. In a multivariate regression analysis model including several confounding factors, UA concentration was an independent predictor of insulin clearance (β = ...Continue Reading

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Citations

Mar 30, 2019·Current Opinion in Cardiology·Matteo Landolfo, Claudio Borghi
Mar 9, 2019·Environmental Science and Pollution Research International·Ram B Jain, Alan Ducatman
Nov 19, 2019·International Journal of Endocrinology·Qing XiongYancheng Xu
Dec 5, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Procolo Di BonitoMelania Manco
Feb 15, 2021·European Journal of Preventive Cardiology·Paolo PalatiniUNKNOWN from the Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

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