Higher than reported adolescent and young adult clinical trial enrollment during the "Golden Age" of melanoma clinical trials

Cancer Medicine
Radhika Sreeraman KumarDamon R Reed

Abstract

Clinical trial enrollments in adolescents and young adults (AYA) with cancer have historically been lower than those in pediatric and older adult populations. We sought to examine therapeutic trial enrollment rates at our cancer center. We performed a retrospective evaluation of AYA patients treated before and after the first checkpoint inhibitor trial opened at our cancer center in 2007. We examined gender, stage at presentation and insurance status in terms of trial enrollment. We compared the trial participation rate of AYA patients with that of older adults. In this adult facility, 12.7% (1,831) of total patients were between age 15 and 39. Overall therapeutic clinical trial rate was 17.6% which increased to 19.8% since 2007. Both nodal disease or metastatic disease at presentation was associated with increasing odds of trial enrollment (OR = 5.36 and P < 0.001 for nodal disease and OR = 7.96 and P < 0.001 for metastatic disease). There was a nonstatistically significant trend toward improved 3-year overall survival in the AYA patients with advanced presentation that enrolled on clinical trials compared with those not enrolled on trials since 2007. AYA clinical trial enrollment at a comprehensive care center melanoma progra...Continue Reading

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Citations

Jul 4, 2018·Pediatric Blood & Cancer·Alice IndiniAndrea Ferrari
Dec 7, 2018·Hematology·Theresa H M Keegan, Helen M Parsons
May 11, 2019·Journal of Oncology Practice·Damon R ReedOdion Binitie
Sep 11, 2019·Journal of Clinical Pharmacology·Solange Corriol-Rohou, S Y Amy Cheung
May 20, 2021·Journal of Adolescent and Young Adult Oncology·Rebecca D SullengerAndrew B Smitherman
Jun 10, 2021·JNCI Cancer Spectrum·Elizabeth J SiembidaMichael E Roth

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