Highlight Article: Different morphological and gene expression profile in placentas of the same sickle cell anemia patient in pregnancies of opposite outcomes

Experimental Biology and Medicine
Letícia C BaptistaMaria Laura Costa

Abstract

Environmentally induced changes in placental morphological and molecular phenotypes may provide relevant insight towards pathophysiology of diseases. The rare opportunity to evaluate the same patient, with sickle cell anemia (SCA), in two different pregnancies, of opposite outcomes (one early onset severe preeclampsia (PE) and the other mostly non-complicated) can prove such concept. In addition, the comparison to other conditions of known placental and vascular/inflammatory involvement strengthens such findings. Our results suggest that the clinical association between SCA and PE can be supported by common pathophysiological mechanisms, but that pathways involving response to copper and triglyceride metabolism may be important drivers of the pathophysiology of PE. Future studies using in a larger number of samples should confirm these findings and explore pathways involved in the pathophysiology of PE and its relationship with SCA.

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Methods Mentioned

BETA
electrophoresis
RNA-Seq
light microscopy

Software Mentioned

STAR
ClustVis
R package DESeq2
edgeR
WebGestalt ( WEB
GEneSeTAnaLysis Toolkit
FastQC

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