Highlights in antiviral drug research: antivirals at the horizon.

Medicinal Research Reviews
Erik De Clercq

Abstract

This review highlights ten "hot topics" in current antiviral research: (i) new nucleoside derivatives (i.e., PSI-352938) showing high potential as a direct antiviral against hepatitis C virus (HCV); (ii) cyclopropavir, which should be further pursued for treatment of human cytomegalovirus (HCMV) infections; (iii) North-methanocarbathymidine (N-MCT), with a N-locked conformation, showing promising activity against both α- and γ-herpesviruses; (iv) CMX001, an orally bioavailable prodrug of cidofovir with broad-spectrum activity against DNA viruses, including polyoma, adeno, herpes, and pox; (v) favipiravir, which is primarily pursued for the treatment of influenza virus infections, but also inhibits the replication of other RNA viruses, particularly (-)RNA viruses such as arena, bunya, and hanta; (vi) newly emerging antiarenaviral compounds which should be more effective (and less toxic) than the ubiquitously used ribavirin; (vii) antipicornavirus agents in clinical development (pleconaril, BTA-798, and V-073); (viii) natural products receiving increased attention as potential antiviral drugs; (ix) antivirals such as U0126 targeted at specific cellular kinase pathways [i.e., mitogen extracellular kinase (MEK)], showing activity a...Continue Reading

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Citations

Jul 24, 2013·Biochemical Pharmacology·Erik De Clercq
Dec 29, 2012·Biochemical Pharmacology·Erik De Clercq
Sep 15, 2016·ACS Infectious Diseases·Na YeJia Zhou
Oct 17, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hanadi SinokrotRafik Karaman
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Apr 10, 2013·Medicinal Research Reviews·Erik De Clercq
Mar 16, 2013·Medicinal Research Reviews·Erik De Clercq
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Nov 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dorota G PiotrowskaJoanna Gotkowska
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Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Freideriki MichailidouRebecca Jane Miriam Goss
Oct 22, 2019·European Journal of Pharmacology·Gabriela Pastuch-GawołekIlona Wandzik
Nov 16, 2019·Chemical Communications : Chem Comm·Sisi GaoJames H Naismith
Jan 18, 2021·International Journal of Biological Macromolecules·Dharma Rao TompaSaraboji Kadhirvel
Jun 10, 2016·Clinical Microbiology Reviews·Erik De Clercq, Guangdi Li

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