Highly active antiretroviral therapy and sexual risk behavior: a meta-analytic review

JAMA : the Journal of the American Medical Association
Nicole CrepazGary Marks

Abstract

Evidence suggests that since highly active antiretroviral therapy (HAART) became available, the prevalence of unprotected sex and the incidence of sexually transmitted infections (STIs) have increased. To conduct 3 meta-analyses to determine whether (1) being treated with HAART, (2) having an undetectable viral load, or (3) holding specific beliefs about HAART and viral load are associated with increased likelihood of engaging in unprotected sex. A comprehensive search included electronic bibliographic databases, including AIDSLINE, MEDLINE, PubMed, CINHAL, PsycInfo, ERIC, EMBASE, and Sociofile, from January 1996 to August 2003, conference proceedings, hand searches of journals, reference lists of articles, and contacts with researchers. Twenty-five English-language studies (some contributing >1 finding) met the selection criteria and examined the association of unprotected sexual intercourse or STIs with receiving HAART (21 findings), having an undetectable viral load (13 findings), or beliefs about HAART and viral load (18 findings). Reports were screened and information from eligible studies was abstracted independently by pairs of reviewers using a standardized spreadsheet. Random-effects models were used to aggregate data....Continue Reading

Associated Clinical Trials

Nov 20, 2015·Laura Whiteley, Laura Whiteley

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