Highly active antiretroviral therapy and viral response in HIV type 2 infection

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Christopher MullinsPhyllis Kanki

Abstract

Human immunodeficiency virus type 2 (HIV-2), the second human retrovirus known to cause AIDS, is endemic to West Africa but is infrequently found outside this region. We present a case series of 10 HIV-2--infected individuals treated in the United States. Physicians applied the principles of highly active antiretroviral therapy (HAART), normally used in treating HIV type 1, with modifications considered appropriate for treating HIV-2. CD4+ cell count, HIV-2 virus load, and clinical status were found to correlate well, providing evidence that HIV-2 virus load is useful in managing treatment of patients with HIV-2 who are receiving therapy. However, HAART regimens with predicted efficacy for treatment of HIV type 1 infection are not as efficacious for treatment of HIV-2. Controlled clinical trials of HIV-2-infected patients receiving various HAART regimens are needed to provide therapeutic guidance to the medical community.

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Citations

Nov 17, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emilia Valadas, Francisco Antunes
Jun 29, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Berta RodésVincent Soriano
Jan 16, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Geoffrey S GottliebUNKNOWN University of Washington-Dakar HIV-2 Study Group
Aug 30, 2007·AIDS Research and Human Retroviruses·Jean RuellePatrick Goubau
Apr 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Antoine BenardUNKNOWN ACHIEV2E Collaboration Study Group
Oct 22, 2010·HIV Medicine·Y GilleeceUNKNOWN BHIVA Guidelines Subcommittee
Jun 20, 2007·Antimicrobial Agents and Chemotherapy·Sherie MasseAkhteruzzaman Molla
Oct 25, 2014·International Journal of Epidemiology·Sanne JespersenUNKNOWN Bissau HIV Cohort study group
Aug 27, 2014·BMC Infectious Diseases·Didier K EkoueviSerge P Eholie
Feb 11, 2016·Journal of the International AIDS Society·Eric BalestreUNKNOWN International Epidemiological Database to Evaluate AIDS (IeDEA) West Africa Collaboration
Feb 9, 2006·The Journal of Antimicrobial Chemotherapy·Berta RodésVincent Soriano
Apr 9, 2008·Expert Review of Vaccines·Aleksandra Leligdowicz, Sarah Rowland-Jones
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Feb 5, 2011·Annals of Saudi Medicine·Reem S AlmaghrabiAbdulrahman A Alrajhi
Jun 30, 2018·AIDS·Nidhi SaraiyaMarilou Corpuz

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