PMID: 9432983Feb 7, 1998Paper

Highly biased CDR3 usage in restricted sets of beta chain variable regions during viral superantigen 9 response

The Journal of Experimental Medicine
C CiurliF Denis

Abstract

Superantigens encoded by the mouse mammary tumor virus can stimulate a large proportion of T cells through interaction with germline-encoded regions of the T cell receptor beta chain like the hypervariable region 4 (HV4) loop. However, several lines of evidence suggest that somatically generated determinants in the CDR3 region might influence superantigen responses. We stimulated T cells from donors differing at the BV6S7 allele with vSAG9 to assess the nature and structure of the T cell receptor in amplified T cells and to evaluate the contribution of non-HV4 elements in vSAG recognition. This report demonstrates that vSAG9 stimulation caused the expansion of TCR BV6-expressing T cells, although to varying degrees depending on the BV6 subfamily. The BV6S7 subfamily was preferentially expanded in all donors, but in donors homozygous for the BV6S7*2 allele, a significant number of BV6S5 T cells were amplified and showed a highly biased beta chain junctional region (BJ) and CDR3 usage. As CDR3 regions are involved in major histocompatibility complex (MHC)-peptide interaction, such a selection is highly suggestive of an intimate MHC-TCR interaction and would imply that the topology of the MHC-vSAG-TCR complex is similar to the one...Continue Reading

References

May 1, 1992·The Journal of Experimental Medicine·M S VacchioR J Hodes
Feb 1, 1993·Immunological Reviews·H Acha-OrbeaH R MacDonald
Apr 1, 1996·The Journal of Experimental Medicine·S C HongC A Janeway
Oct 1, 1996·The Journal of Experimental Medicine·L LiaoD N Posnett

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Citations

Aug 13, 1998·Immunological Reviews·H LiR A Mariuzza
Jun 8, 1999·Annual Review of Immunology·H LiR A Mariuzza
Jan 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean-Simon FortinJacques Thibodeau

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