Highly colloidally stable trimodal 125 I-radiolabeled PEG-neridronate-coated upconversion/magnetic bioimaging nanoprobes

Scientific Reports
Uliana KostivDaniel Horák

Abstract

"All-in-one" multifunctional nanomaterials, which can be visualized simultaneously by several imaging techniques, are required for the efficient diagnosis and treatment of many serious diseases. This report addresses the design and synthesis of upconversion magnetic NaGdF4:Yb3+/Er3+(Tm3+) nanoparticles by an oleic acid-stabilized high-temperature coprecipitation of lanthanide precursors in octadec-1-ene. The nanoparticles, which emit visible or UV light under near-infrared (NIR) irradiation, were modified by in-house synthesized PEG-neridronate to facilitate their dispersibility and colloidal stability in water and bioanalytically relevant phosphate buffered saline (PBS). The cytotoxicity of the nanoparticles was determined using HeLa cells and human fibroblasts (HF). Subsequently, the particles were modified by Bolton-Hunter-neridronate and radiolabeled by 125I to monitor their biodistribution in mice using single-photon emission computed tomography (SPECT). The upconversion and the paramagnetic properties of the NaGdF4:Yb3+/Er3+(Tm3+)@PEG nanoparticles were evaluated by photoluminescence, magnetic resonance (MR) relaxometry, and magnetic resonance imaging (MRI) with 1 T and 4.7 T preclinical scanners. MRI data were obtained o...Continue Reading

References

Oct 19, 2005·Investigative Radiology·Martin RohrerHanns-Joachim Weinmann
Aug 4, 2007·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Meltem IzzetogluKambiz Pourrezaei
Jul 2, 2008·Nature Reviews. Drug Discovery·Jürgen K WillmannSanjiv S Gambhir
Mar 18, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Frans van der HaveFreek J Beekman
Dec 25, 2010·Nanomedicine·Jean-Luc Coll
Jan 1, 2006·Journal of Medical Physics·A K Shukla, Utham Kumar
Jun 1, 2011·Angewandte Chemie·Markus Haase, Helmut Schäfer
Oct 23, 2013·Molecular Diagnosis & Therapy·Lídia CunhaLuís F Metello
Jun 6, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Guangyao ZhaoMitchell A Winnik
Jan 27, 2015·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Peter ČernochPetr Štěpánek
Jan 27, 2015·Chemical Society Reviews·Otto S Wolfbeis
Nov 5, 2015·Nature Nanotechnology·Bo ZhouXiaogang Liu
Feb 6, 2017·International Journal of Molecular Sciences·Sriram SridharBalázs Gulyás
May 10, 2017·Bioconjugate Chemistry·Johoon KimDavid P Cormode
May 14, 2017·Advances in Colloid and Interface Science·A N GeneralovaE V Khaydukov
Jul 9, 2017·Analytical and Bioanalytical Chemistry·Hans H Gorris, Ute Resch-Genger
Aug 22, 2017·Advanced Functional Materials·Haoyuan Huang, Jonathan F Lovell
Apr 11, 2018·ACS Central Science·Dokyoon KimTaeghwan Hyeon
Sep 28, 2018·Analytical Chemistry·Zhiming ZhangYong Zhang
Dec 21, 2018·Methods and Applications in Fluorescence·Gabrielle A MandlJohn A Capobianco
Jan 30, 2019·Methods and Applications in Fluorescence·Blanca Del Rosal, Daniel Jaque
May 7, 2019·Nano Letters·Stefan FischerJennifer A Dionne
Jan 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chengchen DuanZhi Ping Xu

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Methods Mentioned

BETA
X-ray
electron diffraction
dynamic light scattering
imaging techniques

Software Mentioned

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ProcessDiffraction
CONTIN
PMOD
Albira
Atlas
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